Screening and Treatment System for Opiate Dependence

(C-DOSETaP Trial)

NS
NC
Overseen ByNeeraj Chhabra, MD
Age: Any Age
Sex: Any
Trial Phase: Academic
Sponsor: University of Illinois at Chicago
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new system called C-DOSETaP to assist individuals with opioid use disorder (OUD). The researchers aim to determine if the system can enhance OUD screening, improve ongoing health care, increase the use of medications for OUD treatment, and reduce opioid-related deaths in the community. Suitable participants have OUD and receive care at the University of Illinois Hospital and Clinics. As an unphased trial, this study offers participants the chance to contribute to innovative research that could significantly improve OUD treatment and outcomes.

Do I have to stop taking my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that the C-DOSETaP System is safe for patients with opioid use disorder?

Research has shown that the C-DOSETaP System is a new method designed to improve care for people with opioid use disorder (OUD). It enhances screening and treatment by using computerized checks and patient-reported information. As this system is not a medication or direct medical treatment, typical safety concerns like side effects do not apply. Although specific safety data for this system is unavailable, its focus on improving patient care and involvement suggests a low risk of harm. The system aims to connect more patients with proven medications for OUD, such as methadone, buprenorphine, and naltrexone, which are known to be safe. Overall, the C-DOSETaP System is expected to be well-received as it primarily enhances existing care processes.12345

Why are researchers excited about this trial?

Researchers are excited about the C-DOSETaP System because it offers a new way to identify and manage opioid use disorder (OUD), which is different from traditional treatments like methadone or buprenorphine. This system integrates advanced screening with personalized treatment options, potentially allowing for more precise and timely interventions. By focusing on early detection and tailored care, C-DOSETaP aims to improve outcomes for individuals struggling with OUD, addressing a critical need in managing this challenging condition.

What evidence suggests that the C-DOSETaP System is effective for opioid use disorder?

Studies have shown that effective treatment plans for opioid use disorder (OUD) can lower overdose rates and reduce emergency care needs. Research indicates that only a small number of people needing treatment for OUD receive the recommended medications, which are essential for effective management. This trial will evaluate the C-DOSETaP System, designed to improve treatment results by encouraging medication use and ensuring continuous care. Additionally, long-term studies suggest that structured treatment plans can lead to better outcomes over time, such as fewer opioid-related deaths. These findings highlight the potential benefits of comprehensive systems in treating OUD effectively.24678

Who Is on the Research Team?

NS

Niranjan S. Karnik, MD, PhD

Principal Investigator

UIC, College of Medicine

NC

Neeraj Chhabra, MD

Principal Investigator

UIC, College of Medicine

Are You a Good Fit for This Trial?

This trial is for patients aged 16 or older who receive care at the University of Illinois Hospital and Clinics. It is not open to children under 16.

Inclusion Criteria

Participant must be a patient seen at the University of Illinois Hospital and Clinics
I am 16 years old or older.

Exclusion Criteria

I am younger than 16 years old.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

12 months
Ongoing screening across health system

Engagement and Treatment

Implementation of the C-DOSETaP system to improve healthcare engagement and utilization of OUD treatments

12 months
Regular engagement through clinical workflows

Follow-up

Participants are monitored for continuity of care and MOUD utilization

12 months
Follow-up appointments and referrals

Data Analysis and Reporting

Analysis of screening rates, continuity of care, and MOUD utilization, with reporting to health authorities

12 months

What Are the Treatments Tested in This Trial?

Interventions

  • C-DOSETaP System

Trial Overview

The study tests a new system (C-DOSETaP) designed to improve how people with opioid use disorder are identified, treated with medication, and kept connected to ongoing care within a large health network.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Patients with OUDExperimental Treatment3 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Illinois at Chicago

Lead Sponsor

Trials
653
Recruited
1,574,000+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials
2,658
Recruited
3,409,000+

Citations

Comparative Effectiveness of Different Treatment Pathways for ...

This comparative effectiveness research study examines associations between opioid use disorder treatment pathways and overdose and opioid-related acute care ...

C-DIAS PSMG Virtual Grand Rounds

Up to 90% of people with opioid use disorder (OUD) have trauma exposure and up to 41% have posttraumatic stress disorder (PTSD). However, studies estimate that ...

Treatment for Opioid Use Disorder: Population Estimates

In 2022, among the 4% of U.S. adults who needed OUD treatment, only 25% received recommended medications. A larger percentage (30%) received ...

Opioid Use Disorder: Evaluation and Management - NCBI - NIH

Cognitive behavioral therapy is most effective if combined with medications; however, there are mixed results on its effectiveness.[12][24].

Long-Term Treatment Outcomes for Individuals with Opioid ...

This study with 42 months (ie, 3.5 years) of follow-up focuses solely on the outcomes of patients with prescription opioid use disorder.

Project Details

This project seeks to improve screening for opioid use disorder by using computerized screening combined with patient self-reported information.

Effectiveness and safety of therapies for patients with opioid ...

BUP-XR showed borderline significantly lower risk of illicit opioid use versus other BUP-LAI (RR: 1.81; 95% CrI: 0.97–3.55) and buprenorphine ...

Publication Library

Connecting Chronic Pain and Opioid Use Disorder Clinical Trials Through Data Harmonization: Wake Forest IMPOWR Dissemination, Education, and Coordination Center ...