Bup-MBC for Opioid Use Disorder

(Bup-MBC Trial)

TR
Overseen ByThomas Reese, PharmD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Vanderbilt University Medical Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

People receiving buprenorphine-naloxone (bup-nx) for opioid use disorder often face changes in cravings, withdrawal, and return to use risk between clinic visits, but their care team may not know about these changes until the person misses an appointment or returns to drug use. Measurement-based care (MBC) uses brief, repeated check-ins from patients to make these between-visit changes visible. This study tests "Bup-MBC," a strategy that sends patients short questionnaires through their patient portal or by text before and between visits, gives them immediate supportive feedback, shares summary information with their prescriber in the electronic health record, and offers an option to request earlier contact if concerns arise. The study will include providers and patients at outpatient addiction clinics at Vanderbilt University Medical Center, randomly assigned to either receive Bup-MBC or usual care, and followed for 6 months. The main goal is to determine whether Bup-MBC can be practically delivered in routine addiction clinics and whether patients and providers use it.

Are You a Good Fit for This Trial?

This trial is for adults receiving buprenorphine-naloxone treatment for opioid addiction at outpatient clinics. Participants must be able to use a patient portal or receive text messages and are being treated at Vanderbilt University Medical Center.

Inclusion Criteria

Enrolled in and active in the respective clinic
I am 18 years old or older.
I have an active buprenorphine-naloxone prescription from a VUMC addiction clinic.

What Are the Treatments Tested in This Trial?

Interventions

  • Bup-MBC

Trial Overview

The study tests 'Bup-MBC,' which uses short, regular questionnaires sent by text or online to monitor patients' symptoms between visits. Patients get feedback and can request help sooner if needed. Clinics are randomly assigned to use Bup-MBC or continue usual care over 6 months.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Bup-MBCExperimental Treatment1 Intervention
Group II: Usual careActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Vanderbilt University Medical Center

Lead Sponsor

Trials
922
Recruited
939,000+