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Cognitive Control Training for Obsessive-Compulsive Symptoms

(AKILI - OCS Trial)

DD
Overseen ByDana Diaz
Age: < 18
Sex: Any
Trial Phase: Academic
Sponsor: Columbia University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this clinical trial is to learn about brain function and cognition in children ages 8-12 who have subclinical obsessive-compulsive symptoms (OCS), such as unwanted thoughts or repetitive behaviors. The study will also examine whether patterns of brain activity are related to how children respond to cognitive training.

The main questions this study aims to answer are:

* Are there different patterns of brain activity related to cognitive control among children with OCS?

* Are these patterns related to differences in OCS or cognition?

* Can brain activity before training help predict changes in cognitive control or OCS severity after cognitive training?

Participants will:

* Complete clinical interviews, questionnaires, and tests of cognition.

* Have a magnetic resonance imaging scan while completing a cognitive control task.

* Complete video-game-based cognitive training on an iPad for about 25 minutes a day, 5 days a week, for 4 weeks.

* Complete another set of clinical interviews and questionnaires after the training.

Who Is on the Research Team?

DD

Dana Diaz, PhD

Principal Investigator

Columbia University

Are You a Good Fit for This Trial?

This trial is for children ages 8-12 who have mild obsessive-compulsive symptoms, like unwanted thoughts or repetitive behaviors. Children with a full OCD diagnosis or other major health issues may not be eligible.

Inclusion Criteria

Will have definite obsession(s) and/or compulsion(s)
No current or lifetime history of meeting DSM-5 criterion B for OCD
I am between 8 and 12 years old.
See 2 more

Exclusion Criteria

Current or lifetime history of a major medical or neurological problem (e.g., unstable hypertension, seizure disorder, major head trauma)
Active suicidal ideation with some intent to act
Presence of metallic device (ferromagnetic implants or dental braces)
See 4 more

What Are the Treatments Tested in This Trial?

Interventions

  • Cognitive Control Training

Trial Overview

The study tests whether video-game-based cognitive training on an iPad can improve brain function and thinking skills in kids with mild OCD symptoms. Brain scans and interviews are used before and after the training to measure changes.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Cognitive Training for Subclinical Obsessive-Compulsive SymptomsExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Columbia University

Lead Sponsor

Trials
1,529
Recruited
2,832,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+

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