110 Participants Needed

Exercise for Childhood Obesity

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Overseen ByJordan Sill, MD
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: Children's Hospital Medical Center, Cincinnati
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how exercise affects blood fats (lipids) and blood vessel health in young people with obesity. Participants are already part of the Healthworks! structured weight loss program. Ideal candidates are English or Spanish-speaking individuals aged 10-20 with a BMI indicating obesity, enrolled in the Cincinnati Children's Hospital weight loss initiative. As an unphased study, this trial provides a unique opportunity to contribute to understanding the benefits of exercise on health in young people.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What prior data suggests that this exercise program is safe for children and adolescents?

Research shows that exercise is a safe and effective treatment for childhood obesity. Studies have found that exercise programs can significantly improve key health measures such as body mass index (BMI), waist size, and body fat percentage in overweight children and teens. Importantly, exercise is generally well-tolerated and beneficial for both healthy and overweight children, with no serious side effects or safety issues typically associated with structured exercise programs. Participants often feel better and become healthier with regular exercise.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores a structured exercise program specifically tailored for children and teens struggling with obesity. Unlike traditional treatment options that might focus solely on diet modifications or medication, this program emphasizes regular physical activity as a key component for weight loss. The unique aspect of this treatment is its integration with the existing Healthworks! structured weight loss program, providing a comprehensive approach that combines exercise with other lifestyle changes. By targeting physical activity in a structured way, researchers hope to find out how effective exercise can be in tackling childhood obesity compared to other methods.

What evidence suggests that this exercise program is effective for childhood obesity?

Research has shown that exercise can help manage childhood obesity. Programs focused on physical activity have been found to lower BMI—a measure of body fat based on height and weight—and improve children's health. For instance, one study found that exercise programs enhanced fitness, body health, and insulin use in overweight children. Another study demonstrated that school-based exercise programs effectively prevented and treated obesity, particularly in children who were initially more overweight. This trial will evaluate the effectiveness of the Healthworks! structured weight loss program, which includes a structured exercise component, for participants aged 10-20 years. These findings suggest that structured exercise can be a powerful way to help children achieve healthier weights and improve their overall health.12456

Are You a Good Fit for This Trial?

This trial is for young individuals with obesity, specifically those who have a BMI at or above the 95th percentile and are already part of Cincinnati Children's Hospital Healthworks! weight loss program. The study aims to understand how exercise impacts blood fat levels and blood vessel health in these youths.

Inclusion Criteria

I speak English or Spanish.
I am between 10 and 20 years old.
I am considered obese based on my BMI.
See 1 more

Exclusion Criteria

Physician judgement about inability to finish the protocol

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo baseline assessments including Laser flow Doppler test and Veggie Meter readings

1 week
1 visit (in-person)

Intervention

Participants engage in a structured weight loss program with exercise, wearing a Garmin Vivosmart tracker for one week at a time, three times during the study

6 months
Multiple visits (in-person and virtual)

Follow-up

Participants are monitored for changes in triglyceride levels and perfusion units, with assessments at 6 months

6 months
1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Exercise Program

Trial Overview

The intervention being studied is an Exercise Program designed to assess its effects on lipid profiles (fats in the blood) and endothelial function (how well blood vessels work) among obese children and adolescents.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Healthworks! Structured Weight Loss ParticipantsExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Children's Hospital Medical Center, Cincinnati

Lead Sponsor

Trials
844
Recruited
6,566,000+

Citations

Exercise in the treatment of childhood obesity - PMC - NIH

This paper focuses on the basics of exercise therapy, which is extremely beneficial for both healthy and obese children.

Outcomes of a 24-month childhood obesity prevention ...

The primary outcome was change in child body mass index (BMI) z-score at 24 months. Secondary outcomes included number of positive child and parent changes in ...

Physical activity based interventions for reducing body mass ...

This systematic review confirms that physical activity-based interventions can reduce BMI and improve body composition in children aged 6–12 ...

Effectiveness of a population‐scaled, school‐based ...

The population-scaled, school-based PA intervention was effective in preventing and treating obesity. The effects were the greatest in children initially ...

Comparative effectiveness of school-based obesity ...

Improvement of fitness, body composition, and insulin sensitivity in overweight children in a school-based exercise program a randomized, controlled study.

Impact of exercise on anthropometric outcomes in children ...

The results showed that exercise could significantly improve BMI, WC, and BF% in children and adolescents with overweight or obesity, and ...