Steerable Ureteroscopic Renal Evacuation for Kidney Stones

(TRUST Trial)

This trial aims to find the best method for removing kidney stones using two different techniques. The first method employs standard ureteroscopy (URS), where a laser breaks the stones into small pieces. The second method, Steerable Ureteroscopic Renal Evacuation (SURE) with the CVAC System, uses a special tool to see, wash, and extract the stones. Individuals needing kidney stone removal who can attend all trial visits and procedures may be suitable candidates. As an unphased trial, this study allows patients to contribute to innovative research that could enhance kidney stone treatments.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

A recent study found that a new method, steerable ureteroscopic renal evacuation (SURE) using the CVAC System, is safe for treating kidney stones. Research shows that this method is both safe and effective, requiring fewer doctor visits than other treatments. Studies have confirmed its safety and success in removing stones. Overall, SURE with the CVAC System appears well-tolerated, making it a promising option for those dealing with kidney stones.¹²³⁴⁵

Researchers are excited about the Steerable Ureteroscopic Renal Evacuation (SURE) with the CVAC System because it offers a new approach to removing kidney stones. Unlike standard ureteroscopy, which primarily uses lasers to break stones into smaller pieces, the CVAC System integrates vision, irrigation, and aspiration to directly remove stones, fragments, and dust. This method could potentially reduce the need for additional procedures and improve recovery time by efficiently clearing out stone debris. The steerable design of the CVAC System also allows for enhanced precision and control during the procedure, potentially leading to better outcomes for patients.

Research has shown that the Steerable Ureteroscopic Renal Evacuation (SURE) method, using the CVAC system, effectively removes kidney stones. Participants in this trial may receive the SURE method, which studies indicate clears stones thoroughly, leaving fewer fragments behind. This is crucial because leftover pieces can cause further issues. One study found that SURE outperformed traditional methods in completely removing stones. Overall, the CVAC system has proven to be a safe and effective treatment for kidney stones. Meanwhile, other participants in this trial will receive Standard Ureteroscopy (URS), a traditional method that uses a laser to break the stone into small pieces.¹²³⁴⁶