Controlled Diet for Kidney Stones
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how a specific gene mutation affects oxalate production, a compound linked to kidney stones. Participants will follow a special low-oxalate diet and undergo blood and urine tests to measure oxalate levels. The study targets individuals who have had calcium oxalate kidney stones, carry a specific gene mutation, and are willing to adhere to a controlled diet for five days.
As an unphased trial, it offers participants the chance to contribute to groundbreaking research that could lead to new insights and treatments for kidney stones.
What prior data suggests that this dietary intervention is safe?
Previous studies have shown that dietary changes can safely help manage kidney stones. Research indicates that diet can lower the risk of developing stones, with a low-oxalate diet, like the one in this study, proving especially effective.
Regarding glycolate, specific safety data from direct sources is not available. As this is an early-phase study, the safety information may not be as clear as in later-phase studies. However, past research has not associated glycolate with major safety concerns.
Overall, the controlled diet and glycolate appear well-tolerated based on available data. Participants can feel reassured about the safety of these methods.12345Why are researchers excited about this trial?
Researchers are excited about the controlled diet for kidney stones because it offers a non-invasive, dietary approach to managing oxalate levels, which are a key factor in stone formation. Unlike current treatments that often involve medication or surgery, this method focuses on altering diet to naturally reduce oxalate levels. This could potentially minimize side effects and provide a more sustainable, long-term solution for patients. Additionally, the integration of glycolate administration might enhance the effectiveness of the diet, offering a novel combination therapy that has not been extensively explored before.
What evidence suggests that this controlled diet is effective for reducing oxalate levels in kidney stone patients?
Studies have shown that dietary changes can reduce the risk of kidney stones, particularly calcium oxalate stones. Eating the right foods effectively prevents the recurrence of kidney stones. Research indicates that a diet with normal calcium levels and reduced animal protein can lower the chance of stones returning by 51%. Monitoring mineral salt intake also benefits those with kidney stones. Drinking plenty of fluids is known to lower the risk of stones forming again. These findings support the idea that a controlled diet, which participants in this trial will follow, can effectively manage kidney stones.12367
Who Is on the Research Team?
Kyle Wood, MD
Principal Investigator
University of Alabama at Birmingham
Are You a Good Fit for This Trial?
This trial is for people who have had calcium oxalate kidney stones and carry a single (heterozygous) mutation in the AGXT gene, confirmed by genetic testing. Participants must be willing to follow a special low-oxalate diet for five days.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Controlled Dietary Study
Participants consume a controlled low-oxalate diet and provide urine and blood samples to measure oxalate levels
Follow-up
Participants are monitored for safety and effectiveness after the dietary intervention
What Are the Treatments Tested in This Trial?
Interventions
- Controlled Diet
- Glycolate Administration
Trial Overview
The study tests how a controlled low-oxalate diet affects oxalate levels in people with an AGXT gene mutation and kidney stone history. Blood and urine samples will be collected to measure changes.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants will consume the controlled diet for five days. Participants will provide urine and blood samples to measure oxalate levels.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alabama at Birmingham
Lead Sponsor
Citations
Nutrition and Kidney Stone Disease - PMC
Diet modification is an effective method to correct urinary risk factors for kidney stone formation, particularly of the most common stone type calcium oxalate.
2.
cariguidelines.org
cariguidelines.org/guidelines/kidney-stones/nutrition-therapy-for-the-prevention-of-kidney-stones/Nutrition therapy for the prevention of kidney stones
Nutrition therapy is well established in clinical practice as a central strategy for reduction of kidney stone recurrence. High quality evidence ...
Targeted versus empiric approach for prevention of ...
The Emp group had a 33% reduction in dietary oxalic acid intake (p = 0.02), but no significant changes in intakes of water, sodium, animal-based protein, or ...
Kidney Stone Diet Plan and Prevention
A diet low in calcium actually increases your chances of developing kidney stones. Don't reduce the calcium in your diet. Work to cut back on the sodium in ...
5.
2minutemedicine.com
2minutemedicine.com/dietary-changes-and-pharmacologic-interventions-may-prevent-recurrent-nephrolithiasis/Dietary changes and pharmacologic interventions may ...
Pharmacologic interventions were assessed in 23 studies. In adults, thiazide diuretics demonstrated a small reduction in recurrence at 3 years ( ...
Diet, Fluid, or Supplements for Secondary Prevention of ...
High fluid intake decreased risk of recurrent nephrolithiasis. Reduced soft drink intake lowered risk in patients with high baseline soft drink consumption.
Nutritional Management of Kidney Stones (Nephrolithiasis)
Prospective study investigating the influence of nutritional intervention on biochemical profiles in patients with recurrent urolithiasis.
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