Non-invasive Ventilation for Cancer Patients with Respiratory Failure

This trial examines whether a special breathing mask, known as non-invasive positive pressure ventilation (NIPPV), can help cancer patients with breathing problems avoid the need for a tube in their windpipe. Researchers aim to determine if this mask improves oxygen levels and reduces shortness of breath more effectively than the usual method, which involves a tube in the nose. Participants will either use the mask or continue with standard oxygen therapy for up to 28 days. Patients with cancer who struggle to breathe, but do not have cancer in their lungs or severe heart issues, may be suitable for this study. As an unphased trial, this study provides a unique opportunity to explore innovative solutions for breathing difficulties in cancer patients.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Studies have shown that non-invasive positive pressure ventilation (NIPPV) is generally safe for patients. Research indicates that patients with chest tumors found NIPPV both practical and manageable. Another study noted fewer side effects, such as worsening breathing problems or coma, with NIPPV compared to other treatments. Additionally, NIPPV helps avoid complications associated with more invasive breathing support.

Researchers are excited about this trial because it explores two non-invasive ventilation methods for cancer patients facing respiratory failure. The trial compares high flow oxygen therapy, which delivers oxygen at higher rates to help patients breathe easier, with NIPPV (non-invasive positive pressure ventilation), which supports breathing by providing pressure to keep airways open, especially during sleep. Unlike the standard oxygen therapy, which is often continuous, NIPPV offers the flexibility of intermittent use. This approach might provide more personalized care and improve patient comfort. The trial aims to find out which method is more effective at reducing respiratory distress and improving overall patient outcomes.

Research has shown that non-invasive positive pressure ventilation (NIPPV), which participants in this trial may receive, can assist individuals with breathing problems. Studies have found that NIPPV reduces the need for intubation, where a tube is placed in the windpipe to aid breathing. It also improves oxygen levels in the blood for those experiencing sudden breathing difficulties. Some evidence suggests that NIPPV can manage breathing issues in both short-term and long-term conditions. Although data specifically on cancer patients with breathing problems is limited, the overall benefits of NIPPV in similar situations appear promising. Another group in this trial will receive high-flow oxygen therapy, which has supported patients with respiratory failure by providing consistent oxygen levels.¹²⁶⁷⁸