Cancer Screening for Veterans Exposed to Burn Pits
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new method to screen for cancer in veterans exposed to burn pits during their service. The goal is to evaluate the effectiveness of a more intensive screening process and assess participant satisfaction. The study employs tools such as a nasal swab and a blood test, specifically the Avantect Multi-Cancer Detection Test, to detect cancer early. Veterans who have been near burn pits for over a week and have not had cancer in the past five years may qualify for this study.
As an unphased trial, this study provides veterans with a unique opportunity to contribute to groundbreaking research in cancer detection.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this cancer screening protocol is safe for veterans exposed to burn pits?
Research has shown that the Avantect Multi-Cancer Detection Test is being used in studies to help detect cancer in veterans exposed to burn pits. This test screens for cancer using a blood sample. Although specific safety data for this test is unavailable, similar blood tests are generally safe because they require only a blood sample.
The nasal swab collects samples from inside the nose and is usually low-risk. While specific safety data for this swab is not available, nasal swabs are generally well-tolerated and may cause only mild discomfort.
Both the blood test and nasal swab serve as screening methods, making them less invasive and generally safer than treatments for existing conditions. Participants in this trial can expect these procedures to be simple and carry minimal risk.12345Why are researchers excited about this trial?
Researchers are excited about the Avantect Multi-Cancer Detection Test because it offers a novel, non-invasive approach to cancer screening, particularly for veterans exposed to burn pits. Unlike traditional cancer screenings that often rely on invasive procedures or imaging tests, this test uses a simple nasal swab to detect multiple types of cancer. This method is not only more comfortable for patients but also potentially more efficient at catching cancers early, when they are most treatable. The ease and accessibility of this test could make regular cancer screening more feasible and effective for high-risk populations like veterans.
What evidence suggests that this trial's treatments could be effective for cancer screening in veterans exposed to burn pits?
Research has shown that veterans exposed to burn pits face a higher risk of developing cancer. One study found that military personnel have at least a 20% higher cancer risk than average. This trial examines the Avantect Multi-Cancer Detection Test, a blood test designed to detect early signs of cancer, potentially leading to better outcomes. Additionally, the trial includes a nasal swab to assess how burn pit exposure might influence cancer risk. These tools are under evaluation for their potential to detect cancer early, which could be crucial for those at higher risk.13678
Who Is on the Research Team?
Rebecca Kaltman, MD
Principal Investigator
Inova Health Care Services
Stephanie VanBebber
Principal Investigator
Inova Health Care Services
Are You a Good Fit for This Trial?
This trial is for U.S. military veterans aged 35 or older who were exposed to burn pits during deployment (for more than a week) and are able to give consent and authorize use of their health information.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Intensive Cancer Screening
Participants undergo intensive cancer screening at baseline, 12-, and 24-month visits using investigational tools like MCD blood test and nasal swabs
Follow-up
Participants are monitored for cancer status and healthcare utilization, with follow-up assessments at 36 months
Exploratory Analysis
Exploratory analysis using radiomic tools and SYBIL predictive scores to detect malignancy
What Are the Treatments Tested in This Trial?
Interventions
- Avantect Multi-Cancer Detection Test
- Nasal Swab
Trial Overview
The study is testing an intensive cancer screening approach using the Avantect Multi-Cancer Detection blood test and a nasal swab, performed annually over three years, to see how well these tools detect early signs of cancer in veterans exposed to burn pits.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Veteran of the United States Armed Forces (retired/no longer enlisted) with a prior deployment resulting in exposure (based on self-report or official records, if available) to burn pits for \>1 week (exposure defined as on the base or close enough to the base to see the smoke from the burn pit, an area of land used for the open-air combustion of trash and other solid waste products).
Find a Clinic Near You
Who Is Running the Clinical Trial?
Inova Health Care Services
Lead Sponsor
Citations
Cancer Screening for Veterans Exposed to Burn Pits
The goal of this study is to determine the feasibility and participant satisfaction associated with a more intensive cancer screening ...
Burn Pit Exposure in Veterans: A Cancer Screening Pilot ...
The goal of this study is to determine the feasibility and participant satisfaction associated with a more intensive cancer screening regimen in veterans ...
Self-reported exposure to open air burn pits is associated ...
This is the first large-scale study of associations between self-reported burn pit exposures and the development of cancer. Using data from the ...
Long-Term Cancer Risk of US Service Members Exposed to ...
We hypothesized that burn pit exposure increases cancer risk later in life. Methods. A retrospective cohort study was performed to assess long- ...
CDMRP Accelerates Advancements in Cancer Screening for ...
In 2025, the VA acknowledged esophageal, ovarian and prostate cancers, among others, as presumptive cancers related to burn pit exposure.
6.
ctv.veeva.com
ctv.veeva.com/study/burn-pit-exposure-in-veterans-a-cancer-screening-pilot-study-at-the-inova-saville-cancer-screeningBurn Pit Exposure in Veterans: A Cancer Screening Pilot ...
The study hopes to share the premalignant and malignant findings identified and follow-up healthcare utilization associated with high-intensity ...
Airborne Hazards and Burn Pit Exposures - VA Public Health
Information about potential exposure to toxins from burn pits during military service, possible health-related problems and VA benefits.
8.
physicianresources.dana-farber.org
physicianresources.dana-farber.org/news/novel-cancer-screening-test-for-veterans-now-being-offered-at-dana-farber-cancer-instituteNovel Cancer Screening Test for Veterans Now Being Offered ...
The newly opened Sentinel clinical trial will provide veterans with a simple blood test, known as a multi-cancer early detection (MCED) test.
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