Shockwave + Pressure Waves + EMTT for Musculoskeletal Injuries

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Mayo Clinic
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores the effectiveness of different therapies for treating lower-body injuries, such as those affecting muscles, cartilage, and bones. It tests three treatments: electromagnetic transduction therapy (EMTT), focused shockwave therapy (ESWT), and radial pressure wave therapy (EPAT), both individually and in combination. Individuals with a doctor-confirmed lower-body injury who experience daily difficulties may be suitable candidates. However, those with metal implants or certain other conditions may not qualify for some trial components. As an unphased trial, this study provides a unique opportunity to explore innovative treatments that could enhance quality of life.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that these therapies are safe for treating musculoskeletal injuries?

Research has shown that Focused Shockwave Therapy (ESWT) is generally safe and well-tolerated. Studies have found it effective for various muscle and joint conditions, with few side effects reported. As a non-invasive treatment, it does not involve surgery or cutting the skin, and most people experience little to no side effects.

Radial Pressure Waves (EPAT) are also considered safe for most people. However, some individuals might not be suitable for this treatment, so discussing any health concerns with a doctor is important. Like ESWT, EPAT is non-invasive and usually well-tolerated.

Electromagnetic Transduction Therapy (EMTT) has shown promise in reducing pain and improving physical function. Reports indicate only minor side effects, making it another safe option for muscle and joint problems. This therapy is also non-invasive, which generally means fewer risks compared to surgery.

In summary, existing studies consider all three treatments—ESWT, EPAT, and EMTT—safe and well-tolerated, with minimal side effects reported.12345

Why are researchers excited about this trial's treatments?

Researchers are excited about these treatments for musculoskeletal injuries because they offer innovative approaches that could enhance healing and pain relief. Unlike typical treatments like physical therapy and anti-inflammatory medications, these therapies use advanced technologies. Electromagnetic Transduction Therapy (EMTT) utilizes electromagnetic fields to stimulate cellular repair and reduce inflammation. Focused Shockwave Therapy (ESWT) and Radial Pressure Waves (EPAT) apply targeted mechanical waves to promote tissue regeneration and improve blood circulation. By leveraging these unique mechanisms, these treatments have the potential to provide more effective and quicker recovery options for patients.

What evidence suggests that this trial's treatments could be effective for musculoskeletal injuries?

Research has shown that Focused Shockwave Therapy (ESWT) can effectively reduce pain and aid in healing bones, tendons, ligaments, and fascia in individuals with musculoskeletal injuries. It often outperforms other treatments, such as hyaluronic acid, particularly in pain relief. In this trial, some participants will receive shock wave therapy alone, while others will receive it combined with Radial Pressure Waves (EPAT) or Electromagnetic Transduction Therapy (EMTT). Radial Pressure Waves (EPAT) have shown promise, with many patients experiencing significant improvements in pain and movement, especially for conditions like plantar fasciitis. Electromagnetic Transduction Therapy (EMTT) has proven effective in enhancing physical function and reducing pain in degenerative musculoskeletal conditions, with few side effects. This trial studies these therapies for their potential to heal and alleviate pain in musculoskeletal injuries.13678

Who Is on the Research Team?

EB

Elizabeth Bondi

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for adults over 18 who have a doctor-confirmed injury to the muscles, bones, or soft tissues of their legs or lower body.

Inclusion Criteria

I am over 18 and have a doctor-confirmed leg or lower body injury.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive ESWT, EPAT, EMTT, or a combination of these therapies for lower extremity musculoskeletal injuries

6-8 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Electromagnetic Transduction Therapy (EMTT)
  • Focused Shockwave (ESWT)
  • Radial Pressure Waves (EPAT)

Trial Overview

The study is testing three non-invasive treatments—shockwave therapy (ESWT), radial pressure waves (EPAT), and electromagnetic transduction therapy (EMTT)—alone and in combination to see how well they help heal lower limb injuries.

How Is the Trial Designed?

4

Treatment groups

Experimental Treatment

Group I: shock wave onlyExperimental Treatment1 Intervention
Group II: shock wave + radial pressure waveExperimental Treatment2 Interventions
Group III: shock wave + EMTTExperimental Treatment2 Interventions
Group IV: EMTTExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

Citations

Extracorporeal magnetotransduction therapy (EMTT ... - PMC

Conclusions. EMTT appears effective in improving physical function and reducing pain in degenerative musculoskeletal conditions, with minor side effects.

2.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/41313312/

Extracorporeal magnetotransduction therapy (EMTT) for ...

ConclusionsEMTT appears effective in improving physical function and reducing pain in degenerative musculoskeletal conditions, with minor side ...

Extracorporeal magnetotransduction therapy (EMTT) for ...

EMTT appears effective in improving physical function and reducing pain in degenerative musculoskeletal conditions, with minor side effects.

Electromagnetic Transduction Therapy (EMTT) Enhances ...

Initial clinical trials have shown promising results in low back pain, demonstrating safety and efficacy [17]. Furthermore, studies on Achilles tendinopathy ...

EMTT: studies, effects & scientific evidence

EMTT is based on clinical studies and shows improvements in pain and function. Learn more about its effects and scientific background.

Electromagnetic Transduction Therapy (EMTT) Enhances ...

Our results indicate that EMTT affects tenocyte differentiation and collagen production, both essential in tendon injury repair. In addition, to ...

EMTT for Musculoskeletal Disorders

As one of the newest and most innovative technologies to treat chronic musculoskeletal diseases, EMTT is evidence-based, non-invasive, and an exceptional ...

Electromagnetic transduction therapy in non-specific low ...

A prospective randomised controlled trial to investigate the efficacy of electromagnetic transduction therapy (EMTT) for treatment of patients with non- ...