Online Wellness Program for Multiple Sclerosis

(DEW Trial)

The goal of this clinical trial is to learn if an online wellness program can lower fatigue and improve mood and quality of life in people with progressive multiple sclerosis who are 45 to 70 years old and are experiencing significant fatigue disability.

The main questions it aims to answer are:

* Does the online wellness program lower fatigue after 3 months and further lower fatigue after 6 months?

* Does the online wellness program improve anxiety, depression, and quality of life after 3 months and lead to additional improvements after 6 months? Researchers will compare participants who receive immediate access to the online wellness program with participants who continue their usual care and receive access to the program after the study ends.

Participants will:

* Complete online surveys at the start of the study, at 3 months, and at 6 months. Each survey session takes less than 1 hour.

* Complete a 7-day run-in period before randomization to confirm their interest and ability to complete study activities.

* Be assigned by chance to either the online wellness program group or the wait-list control group.

Participants in the online wellness program group will:

* Receive access to the "Creating Health" online course through the University of Iowa Canvas platform.

* Work through five self-paced education modules over 6 months. Topics include nutrition, stress management, and physical activity.

* Have access to monthly group coaching calls by Zoom.

* Have access to an online exercise platform.

* Have access to email and text support from the study team.

Participants in the wait-list control group will:

* Continue their usual diet, lifestyle, and medical care during the 6-month study period.

* Complete the same study surveys as the intervention group.

* Receive full access to the online wellness program, online exercise platform and support materials after completing their final 6-month surveys.

At the end of the study, all participants will complete final surveys about their symptoms, quality of life, and their experience with the program. Active study participation ends after the 6-month assessments are completed.