Repetitive Transcranial Magnetic Stimulation for Multiple Sclerosis

(CeV Trial)

This trial examines how repetitive transcranial magnetic stimulation (rTMS) might aid individuals with multiple sclerosis (MS) in improving their walking. rTMS uses magnetic pulses to stimulate brain regions and could potentially address walking difficulties caused by MS. The trial will compare real rTMS treatment with a sham (fake) version to assess the actual changes it can produce. Individuals with MS who experience walking challenges and have not changed their MS medication in the past month might be suitable candidates for this trial. As an unphased trial, this study provides a unique opportunity to explore innovative treatment options for enhancing mobility in MS patients.

The trial does not require you to stop your current medications, but you cannot start new medications for spasticity or stimulants during the study. If you are already taking fampridine, you can continue as long as you started it more than 30 days before the trial.

Research has shown that repetitive transcranial magnetic stimulation (rTMS) is generally safe and well-tolerated for people with multiple sclerosis (MS). In one study, participants underwent 20 sessions of rTMS, and the results indicated that the treatment was safe and manageable. Another study found that rTMS helped reduce symptoms like muscle stiffness without causing major side effects. Overall, evidence suggests that rTMS can be a safe option for those with MS, offering potential improvements in certain symptoms without significant risks.¹²³⁴⁵

Repetitive Transcranial Magnetic Stimulation (rTMS) is unique because it uses magnetic pulses to stimulate specific areas of the brain, which is different from the standard treatments for multiple sclerosis (MS) that typically focus on immune system modulation or symptom management. Most MS treatments involve drugs that are administered orally or via injection to slow disease progression or manage symptoms. However, rTMS offers a non-invasive alternative that directly targets brain activity. Researchers are excited about rTMS because it could potentially improve neurological function and quality of life for MS patients without the systemic side effects associated with traditional medications.

Research has shown that repetitive Transcranial Magnetic Stimulation (rTMS), which participants in this trial may receive, might help people with Multiple Sclerosis (MS) walk better. Studies have found that rTMS can reduce muscle stiffness, easing movement. One study discovered that rTMS lowered the frequency and severity of muscle spasms in MS patients, with effects lasting up to a month. Additionally, rTMS has shown potential in improving other MS symptoms like depression and fatigue. These findings suggest that rTMS could be beneficial for those with MS-related walking difficulties.³⁶⁷⁸⁹