Time Restricted Eating for Multiple Sclerosis

(Meal Time MS Trial)

This trial explores how meal timing affects the health of people with multiple sclerosis (MS), a condition where the immune system attacks the protective covering of nerves. Researchers aim to determine if eating within a specific time window each day, known as Time Restricted Eating, can improve markers of nerve health and reduce inflammation. Participants will follow either an 8-hour eating schedule or a 12-hour or more eating schedule without changing the type or amount of food they consume. Individuals with relapsing-remitting or secondary progressive MS who manage their own eating schedule and have access to a smartphone might be suitable for this trial. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance MS management strategies.

The trial does not specify if you need to stop taking your current medications. However, if you are on disease modifying therapy (DMTs), you must have been stable on it for 6 months to participate.

Research has shown that time-restricted eating (TRE) is generally safe for people with multiple sclerosis (MS). Various studies, including those on intermittent fasting—a similar concept—indicate that participants adapted well to the dietary changes without major side effects.

For example, one study found that TRE was safe and even led to benefits such as weight loss and improved metabolism in people with MS. Another review found that fasting-mimicking diets, similar to TRE, are also safe for this group.

Unlike standard treatments for multiple sclerosis, which often involve medications like interferons, glatiramer acetate, or monoclonal antibodies, time-restricted eating offers a non-pharmaceutical approach. This method is unique because it focuses on when you eat rather than what you eat, potentially influencing the body's internal clock and immune system without altering diet content. Researchers are excited about this trial because it could provide a simpler, lifestyle-based option that complements existing therapies and might help manage symptoms or reduce disease progression in an entirely new way.

Research has shown that time-restricted eating (TRE) might benefit people with multiple sclerosis (MS). Studies have found that intermittent fasting, including TRE, can reduce pain and fatigue and improve thinking and memory in MS patients. One study discovered that TRE aided in weight loss and improved heart and metabolic health in an individual with MS. Additional research suggests it may also alter immune cell behavior, potentially helping manage MS symptoms. In this trial, participants will join either a Time Restricted Eating arm, eating all meals within 8 hours per day, or an Unrestricted Eating arm, consuming meals over 12 or more hours per day. While more research is needed, early findings are promising for TRE's potential to improve brain health in MS.¹²³⁴⁵