Functional Balance Intervention for Multiple Sclerosis

(HomeFBIinMS Trial)

This trial tests a new balance training program for people with multiple sclerosis (MS). The goal is to determine if this multicomponent balance intervention can improve physical abilities, thinking skills, and everyday activities more effectively than a usual stretching routine. Participants will either try the new balance exercises or continue with stretching, both performed at home with some assistance. It suits those with MS who can stand up from a chair independently and haven't recently undergone balance therapy. Sessions are virtual, so internet access and a buddy to assist are important. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance daily living for those with MS.

The trial requires that participants have been on stable disease-modifying therapy for at least 6 months, but it excludes those using sedative medications, Alzheimer's/dementia-modifying drugs, antidepressants, or anxiety medications. If you are taking any of these, you may need to stop before participating.

Research has shown that the Functional Balance Intervention (FBI) for people with multiple sclerosis (MS) is under study to assess its effects on physical and mental abilities. Although detailed safety information from past studies is lacking, this early-phase trial tests the treatment's safety in humans.

This intervention is non-invasive, meaning it doesn't involve surgery or entering the body. It includes exercises focusing on balance, strength, and coordination, which are generally safe in other contexts. A "Helper Buddy" supports participants during sessions, emphasizing safety.

Researchers are excited about the Functional Balance Intervention for multiple sclerosis because it combines physical and cognitive training in a home-based program. Unlike traditional treatments that often focus solely on physical therapy or medication, this approach integrates strength, agility, and dual-task exercises with cognitive tasks, aiming to improve both physical balance and mental processing. The inclusion of computer-based stepping games and vestibular exercises, like gaze stabilization and head turn walking, is unique and may offer a more holistic improvement in balance and coordination. This innovative method could potentially enhance quality of life by addressing multiple aspects of motor and cognitive function simultaneously.

Research has shown that the Functional Balance Intervention (FBI), which participants in this trial may receive, can greatly improve balance and quality of life for people with multiple sclerosis (MS). One study found that virtual training programs like the FBI helped people balance better than traditional exercises. Another review of studies showed that balance-focused activities can reduce falls and improve stability in adults with MS. These findings suggest that the FBI could enhance physical and mental functions, as well as daily activities, for people with MS.¹²³⁵⁶