60 Participants NeededMy employer runs this trial

Exercise Training for Chronic Obstructive Pulmonary Disease

(ReV UP COPD Trial)

LF
Overseen ByLindsay Forbes, MD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Colorado, Denver
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how exercise affects heart function in people with chronic obstructive pulmonary disease (COPD), a lung condition that makes breathing difficult. Researchers focus on the heart's right side and its response during rest and exercise. By identifying patterns in heart function, the study aims to improve future COPD treatments. Individuals diagnosed with COPD, over 40, and not currently experiencing a flare-up might be suitable for this trial. As an unphased trial, it offers participants the chance to contribute to groundbreaking research that could enhance COPD management.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications. However, if you have changed your COPD therapy in the 3 weeks before joining, you may not be eligible to participate.

What prior data suggests that exercise training is safe for individuals with COPD?

Research has shown that exercise is generally safe for people with chronic obstructive pulmonary disease (COPD). Studies have found that exercise can improve lung function, increase exercise capacity, and enhance quality of life for these patients. For example, one study found that aerobic exercise helped people with COPD walk longer distances and reduced their symptoms.

Another study demonstrated that high-intensity interval training benefited lung function and overall health. Importantly, these studies did not report any major safety concerns or negative effects from exercise. This suggests that most people with COPD can handle exercise well.12345

Why are researchers excited about this trial?

Exercise training is unique because it offers a non-pharmacological approach to managing Chronic Obstructive Pulmonary Disease (COPD). Unlike traditional treatments, such as bronchodilators and steroids that aim to open airways and reduce inflammation, exercise training targets the cardiovascular system, specifically improving right ventricular function. Researchers are excited about this because it could enhance heart and lung efficiency, potentially improving quality of life and physical endurance for people with COPD without the side effects associated with medications.

What evidence suggests that exercise training might be an effective treatment for COPD?

Studies have shown that exercise can greatly help people with chronic obstructive pulmonary disease (COPD). Research indicates that exercise enables individuals to engage in more physical activities without tiring easily. High-intensity interval training (HIIT) improves lung function and enhances quality of life for those with COPD. Pulmonary rehabilitation, which includes exercise, plays a crucial role in reducing symptoms like shortness of breath and increasing exercise capacity. Overall, regular exercise can ease daily tasks and enhance well-being for people with COPD. Participants in this trial will undergo exercise training to assess its impact on right ventricular dysfunction in COPD.12678

Who Is on the Research Team?

LF

Lindsay Forbes, MD

Principal Investigator

University of Colorado, Denver

Are You a Good Fit for This Trial?

This trial is for people aged 40 or older with COPD whose lung function tests show obstruction. Participants should not have had recent changes in COPD treatment, severe heart problems, active cancer (except skin), very high oxygen needs, recent COPD flare-ups, or other serious health issues that make exercise unsafe.

Inclusion Criteria

I have been diagnosed with COPD.
I am 40 years old or older.

Exclusion Criteria

Change in COPD therapy in the 3 weeks prior to enrollment
I need more than 10 liters per minute of oxygen when I am active.
I currently have another active cancer besides skin cancer.
See 16 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Testing

Participants complete cardiopulmonary exercise testing (CPET) and transthoracic echocardiography (TTE) during rest, moderate- and high-intensity exercise

1-2 weeks
1 visit (in-person)

Exercise Training Intervention

Participants undergo a targeted exercise training intervention based on their RV contractile response during baseline testing, performed 3x/week for 12 weeks on an upright stationary bicycle

12 weeks
36 visits (in-person)

Post-Intervention Testing

Participants repeat CPET and TTE to determine the impact of exercise training on right ventricular dysfunction and complete a health-related quality of life questionnaire

1-2 weeks
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the intervention, including exercise training safety and feasibility

4 months

What Are the Treatments Tested in This Trial?

Interventions

  • Exercise training

Trial Overview

The study looks at how the right side of the heart responds to different levels of exercise in people with COPD. It involves supervised and possibly remote exercise training sessions to monitor heart function during rest and moderate-to-high intensity activity.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: COPDExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Colorado, Denver

Lead Sponsor

Trials
1,842
Recruited
3,028,000+

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Trials
3,987
Recruited
47,860,000+

Citations

Exercise Prescription Training in Chronic Obstructive ... - PMC

Exercise rehabilitation training has emerged as one of the most promising modalities for enhancing clinical outcomes and overall well-being in patients with ...

Effects of different exercise regimens on prognosis of patients ...

Exercise interventions have a positive effect on the treatment of patients with COPD, significantly improving functional capacity, aerobic capacity, and ...

High-intensity interval training improves the outcomes of ...

HIIT may be beneficial to improve the pulmonary function, exercise capacity and quality of life of patients with COPD, which is worthy of clinical promotion.

Meta-Analysis of the Effect of Aerobic Exercise Combined ...

Conclusion: The results showed that this combination therapy significantly improved the patient's exercise endurance, effectively alleviated the symptoms of ...

Effectiveness of an exercise training programme COPD in ...

Pulmonary rehabilitation (PR) is very effective in improving exercise capacity, dyspnoea and quality of life in patients with moderate to severe COPD [4].

Clinical effect of aerobic exercise training in chronic...

The aerobic exercise training intervention contributed to an increasing in 6MWD and decrease in CAT scores and mMRC grades, as well as improving ...

Exercise Training in Chronic Obstructive Pulmonary Disease

Relatively few data exist assessing outcomes of UE training compared with those available for LE training. Upper extremity training may consist of endurance ...

COPD and exercise: does it make a difference?

Exercise training has been identified as the best available means of improving muscle function and exercise tolerance in patients with COPD.