60 Participants Needed

Resistance Training for Parkinson's Disease

EJ
JF
Overseen ByJoseph F. Signorile, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Miami
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how different types of resistance training can improve muscle strength and daily performance in people with Parkinson’s disease. It compares the effects of high-load (heavier weights) versus low-load (lighter weights) resistance training. Participants will attend training sessions twice a week for up to 12 weeks. This trial suits individuals with Parkinson's who can walk 50 meters without assistance and communicate in English. As an unphased study, it offers participants the chance to contribute to valuable research that could enhance daily life for those with Parkinson’s.

Do I need to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that both heavy and light weightlifting exercises can be safe for people with Parkinson's disease. Studies on heavy weightlifting indicate it is well-tolerated and helps improve muscle strength and function, with few reports of muscle damage or injury. This suggests it is generally safe for those with mild to moderate Parkinson's disease.

For light weightlifting, studies confirm it can significantly increase muscle strength. It is also considered safe and beneficial, with no major negative effects reported.

Both types of exercise appear safe for people with Parkinson's disease, with no significant safety concerns noted in previous studies.12345

Why are researchers excited about this trial?

Researchers are excited about using resistance training for Parkinson's disease because it offers a novel approach that focuses on building strength and improving motor function. Traditional treatments for Parkinson's typically involve medications like Levodopa to manage symptoms. However, resistance training targets muscle strength and endurance directly, potentially enhancing mobility and quality of life. High-load and low-load resistance training variations allow for tailored programs that can accommodate varying levels of patient strength and preference. This method could complement existing therapies, providing a more holistic approach to managing Parkinson’s symptoms.

What evidence suggests that this trial's treatments could be effective for Parkinson's disease?

This trial will compare High-Load Resistance Training with Low-Load Resistance Training for individuals with Parkinson's disease. Research has shown that resistance training, whether using heavy or light weights, can enhance muscle strength and power in people with Parkinson's disease. High-Load Resistance Training can improve the coordination between nerves and muscles, which is crucial for everyday tasks. Studies suggest that Low-Load Resistance Training can significantly increase muscle strength, making it suitable for those with mild to moderate Parkinson's. Both types of training effectively address movement problems in Parkinson's. This evidence supports the idea that resistance training can improve strength and daily activities for people with Parkinson's.24678

Who Is on the Research Team?

JF

Joseph F. Signorile, PhD

Principal Investigator

University of Miami

Are You a Good Fit for This Trial?

This trial is for older adults with Parkinson's disease who can walk 50m without help, understand and communicate in English, are in stages 1-3 of the disease's progression, and have a MoCA score above 18.

Inclusion Criteria

I can walk 50 meters without help.
I can understand and communicate in English.
My Parkinson's is in the early to mid-stages (1-3).
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either low-load or high-load resistance training, twice per week for at least 24 sessions over 12 weeks

12 weeks
24 visits (in-person)

Follow-up

Participants are monitored for changes in neuromuscular performance and functional tests after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • High-Load Resistance Training
  • Low-Load Resistance Training

Trial Overview

The study is testing whether high-load or low-load resistance training is more effective at improving muscle strength, power, and daily performance tasks in those with Parkinson's disease.

How Is the Trial Designed?

2

Treatment groups

Active Control

Group I: Low-Load Resistance TrainingActive Control1 Intervention
Group II: High-Load Resistance TrainingActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Miami

Lead Sponsor

Trials
976
Recruited
423,000+

Citations

Effectiveness of aerobic and resistance training on the motor ...

Aerobic and resistance training are common complementary therapies to improve motor symptoms in people with Parkinson's disease (PD).

Maximal strength training in patients with Parkinson's disease

In conclusion, this study shows that MST improves FGC, neuromuscular function, and functional performance and advocates that high-intensity ...

Progressive resistance exercise improves strength and ...

This review suggests that progressive resistance exercise can be effective and worthwhile in people with mild to moderate Parkinson's disease.

Systematic review on strength training in Parkinson's disease

The study reported by Schlenstedt et al showed an improvement in muscle strength both in the strength training group and control group, but the data are not ...

Effects of Moderate‐Volume, High‐Load Lower‐Body ...

Resistance training research has demonstrated positive effects for persons with Parkinson′s disease (PD), but the number of acute training ...

Evidence of Rehabilitative Impact of Progressive Resistance ...

The aim of this umbrella review was to provide evidence that PRT improves strength in PD, and the results favor the inclusion of strengthening exercises in the ...

The Safety and Feasibility of High-Force Eccentric ...

To examine the effect of high-force eccentric resistance exercise on measures of muscle damage and injury in persons with mild to moderate Parkinson's disease ( ...

Effects of Moderate-Volume, High-Load Lower-Body ... - PMC

The safety and feasibility of high-force eccentric resistance exercise in persons with Parkinson's disease. Archives of Physical Medicine and Rehabilitation ...