Percepta for Memory
(PFCO Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a dietary supplement called Percepta, which contains extracts from cat's claw bark and oolong tea. The goal is to determine if Percepta can improve memory and brain health in individuals with mild memory problems. Participants will take either the supplement or a placebo for six months, enabling researchers to compare the effects. Ideal candidates are English-speaking adults in the U.S. who have noticed mild memory issues and own an Oura Ring for tracking health data. As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research on memory enhancement.
Will I have to stop taking my current medications?
Yes, if you are currently taking medications or supplements that affect cognition, like donepezil or memantine, you will need to stop taking them to participate in this trial.
Is there any evidence suggesting that Percepta is likely to be safe for humans?
Research has shown that Percepta, a dietary supplement made from cat's claw bark and oolong tea extracts, effectively breaks down harmful brain proteins in lab studies. However, its safety for humans remains unknown. Although marketed for memory support, this trial aims to gather initial safety information.
As an early-phase study, the primary focus is on understanding safety and potential effects on the brain. Early-phase trials often involve testing treatments in humans for the first time, so researchers are still collecting safety data. Participants will be closely monitored for side effects or unexpected reactions through wearable devices and self-reporting. While Percepta is designed to support brain health, participants should remember it is still experimental and report any unexpected reactions to the trial team.12345Why are researchers excited about this trial?
Unlike the standard treatments for memory decline that often involve pharmaceuticals targeting neurotransmitter levels, Percepta is unique because it is a plant-based dietary supplement. It combines PTI-00703® Cat's Claw bark extract and MemorTea™ oolong tea extract to address cognitive decline. Researchers are excited because it targets underlying mechanisms like neuroinflammation, oxidative stress, and the buildup of amyloid-beta plaques and tau tangles, which are linked to memory issues. This multifaceted approach offers a natural alternative with the potential for fewer side effects compared to conventional medications.
What evidence suggests that Percepta might be an effective treatment for mild cognitive impairment?
Research suggests that Percepta, a dietary supplement made from Cat's Claw and oolong tea extract, may help improve brain function. Studies have shown that one of its ingredients, PTI-00703, can reduce harmful brain deposits linked to memory problems. Lab tests conducted outside the human body found Percepta to be very effective in breaking down these deposits. Early research on people indicates that Percepta might help improve memory in those with mild memory issues. Additionally, animal studies have shown promising results, such as reduced brain plaque and improved memory. Participants in this trial will receive either Percepta or a placebo to further evaluate its effects on memory.24567
Are You a Good Fit for This Trial?
This trial is for adults aged 40-85 who have noticed mild problems with memory or thinking. Participants should be able to take a daily supplement and use remote monitoring devices at home.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants self-administer the study supplement or placebo daily for 6 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
Optional Extension
Potential extension to 12 months based on interim analysis results
What Are the Treatments Tested in This Trial?
Interventions
- Percepta
Trial Overview
The study tests Percepta, a dietary supplement made from cat's claw and oolong tea extracts, against a placebo. Participants are randomly assigned to either group and take the product daily for 6 months while their cognitive function and sleep are monitored remotely.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Participants in this arm will self-administer Percepta, a proprietary plant-based dietary supplement, orally once daily for a duration of 6 months. The daily dosage consists of 2 capsules totaling 750 mg. The supplement comprises PTI-00703® Cat's Claw (Uncaria tomentosa) bark extract and MemorTea™ oolong tea extract. Participants are instructed to take the capsules in the morning, preferably with a light meal, to minimize potential sleep disruption caused by the natural caffeine content found in the oolong tea extract. Percepta is designed to target underlying mechanisms of cognitive decline, including neuroinflammation, oxidative stress, and the accumulation of amyloid-beta plaques and tau tangles. Protocol adherence is monitored daily through the Reputable Health mobile application.
Participants in this arm will self-administer a matched placebo supplement orally once daily for a duration of 6 months. The placebo consists of capsules containing an inert substance, devoid of the active Percepta ingredients (PTI-00703® Cat's Claw and MemorTea™ oolong tea extracts). To maintain the double-blind design, the placebo capsules are manufactured to be visually identical in size, color, and packaging to the active intervention. The dosing regimen mirrors the active arm: participants are instructed to take 2 capsules in the morning, preferably with a light meal. Adherence is tracked daily via the Reputable Health mobile application. This arm serves as a comparator to isolate the specific effects of Percepta from potential placebo responses.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Cerebrum DAO Association
Lead Sponsor
Reputable Health
Collaborator
Citations
Percepta for Cognitive Optimization - ClinicalTrials.Veeva
This Phase 1, randomized, double-blind, placebo-controlled trial evaluates the cognitive and neurophysiological effects of a dietary ...
2.
alzdiscovery.org
alzdiscovery.org/uploads/cognitive_vitality_media/PTI-00703-Cognitive-Vitality-For-Researchers.pdfPTI-00703
PTI-00703 is an extract from a cat's claw species called Uncaria tomentosa (a Peruvian source) and was identified as having Aβ- and tau tangle- reducing ...
In vitro comparison of major memory-support dietary ... - PMC
Percepta (PTI-00703 cat's claw and a specific oolong tea extract) was determined to be the most effective and potent memory support dietary ...
4.
catalyst.molecule.xyz
catalyst.molecule.xyz/projects/37627217292950168582806594751056837508226390515778803553953686081711504531171Boosting the Brain - Developing Percepta® with Cat's Claw ...
Emerging human clinical data shows that Percepta® may support memory improvement in patients with memory loss, mild cognitive impairment (MCI), and early ...
Combating Memory Loss and Cognitive Decline - Percepta
In vitro and animal studies show promising results, including reduced brain plaque and improved memory in rodent models.
Study Details | NCT07612449 | Percepta for Cognitive ...
Percepta is designed to target underlying mechanisms of cognitive decline, including neuroinflammation, oxidative stress, and the accumulation ...
In vitro comparison of major memory-support dietary ...
We show that percepta has the most potent ability to disaggregate/reduce Aβ 1-42 fibrils and tau protein paired helical/straight filaments.
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