Transcranial Magnetic Stimulation for Cannabis Use Disorder

(CAPE Trial)

This trial aims to determine if transcranial magnetic stimulation (TMS) can help individuals recognize issues related to their cannabis use. TMS is a non-invasive method that influences brain activity. Researchers seek to understand if altering activity in a specific brain area affects individuals' perceptions of their cannabis habits. Participants will undergo various types of TMS, including active continuous theta burst stimulation (cTBS), active intermittent theta burst stimulation (iTBS), and sham TMS, and will answer questions to assess any changes. Suitable candidates have severe cannabis use disorder, regularly use cannabis, and face cannabis-related issues in daily life. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research on cannabis use and brain activity.

Yes, if you are currently taking any daily psychotropic medication, you will not be eligible to participate in this trial.

A previous study found that the safety of transcranial magnetic stimulation (TMS) is similar for people with substance use disorders (SUDs) and the general population. This finding indicates that TMS can be safely used for those with SUDs, including cannabis use disorder (CUD). Research on two types of TMS, intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS), shows that these treatments are generally well-tolerated. Side effects are usually mild and may include headaches or scalp discomfort, but these effects are typically short-lived. Overall, many studies have considered TMS safe for those with substance use issues.¹²³⁴⁵

Researchers are excited about using Transcranial Magnetic Stimulation (TMS) for Cannabis Use Disorder because it offers a non-invasive approach that directly targets brain activity. Unlike traditional treatments, which often rely on behavioral therapies or medications to manage symptoms, TMS uses magnetic fields to stimulate specific brain regions, potentially reducing cravings and dependency. This technique, including its variations of continuous (cTBS) and intermittent theta burst stimulation (iTBS), allows for a more tailored approach to modifying brain circuits involved in addiction. Moreover, the inclusion of a sham component helps ensure the validity of the effects observed, making it a promising avenue for those who have not responded to standard treatments.

Research has shown that transcranial magnetic stimulation (TMS) can assist with substance use issues, such as cannabis use disorder (CUD). This trial will compare different TMS approaches. Participants may receive intermittent theta burst stimulation (iTBS), which studies have shown reduces focus on drug-related cues and cravings. Others may receive continuous theta burst stimulation (cTBS), which evidence suggests can safely decrease cannabis use frequency. Additionally, some participants will receive a sham TMS treatment for comparison. Overall, TMS is considered safe and might offer a new way to help those with cannabis use problems.²⁵⁶⁷⁸