Physiatry-Led Prehabilitation for Ovarian Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether a specialized pre-surgery program can help women with stage III-IVA gynecologic cancer improve their physical and mental health before surgery. The program, called physiatry-led prehabilitation, aims to enhance patients' overall function and well-being. It includes personalized exercise, nutrition, and mental health goals. Patients with stage III-IVA gynecologic cancer who plan to start treatment at City of Hope Orange County and are ready to engage in a home-based program may be suitable candidates for this trial. As an unphased trial, this study offers patients the chance to contribute to innovative care strategies that could enhance pre-surgery preparation and recovery.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that physiatry-led cancer prehabilitation is safe for gynecologic cancer patients?
Research has shown that physiatry-led cancer prehabilitation is generally safe and well-tolerated. Studies have found that this type of prehabilitation can improve walking ability and reduce complications after surgery. For instance, one study found that over 77% of patients walked better before their surgery. Another review indicated that prehabilitation can lower the risk of lung and other complications, improve heart function, and aid recovery after surgery.
These findings suggest that prehabilitation not only helps patients physically prepare for surgery but also does so safely, without major side effects. Overall, the evidence supports the safety and positive impact of physiatry-led cancer prehabilitation on patients' recovery and quality of life.12345Why are researchers excited about this trial?
Researchers are excited about the physiatry-led cancer prehabilitation for ovarian cancer because it offers a holistic approach that integrates physical, nutritional, and psychospiritual support. Unlike standard treatments that primarily focus on chemotherapy or surgery, this method empowers patients to actively participate in their care through a home-based program. It includes aerobic and resistance exercises, personalized nutrition guidance, and mental health support, all tailored to each patient's needs. This comprehensive approach aims to enhance overall well-being and potentially improve recovery outcomes, setting it apart from traditional treatment options.
What evidence suggests that physiatry-led prehabilitation is effective for improving function in stage III-IVA gynecologic cancer patients?
Research has shown that prehabilitation, led by physical medicine specialists, benefits ovarian cancer patients. In this trial, participants will receive physiatry-led prehabilitation, which prepares them for surgery by enhancing physical and mental health. For example, more than 77% of patients in a prehabilitation program improved their walking ability before surgery. This approach also aids recovery after surgery, improving it by 60% and reducing complications by 40%. Patients undergoing prehabilitation often tolerate chemotherapy better, with fewer needing to lower their doses. Overall, prehabilitation helps patients feel better and recover more quickly.23467
Who Is on the Research Team?
Jessica Cheng
Principal Investigator
City of Hope Medical Center
Are You a Good Fit for This Trial?
This trial is for adults diagnosed with stage III-IVA gynecologic cancers, such as ovarian cancer, who are about to start systemic treatment before surgery. Participants should be able to take part in rehabilitation activities and follow instructions from the care team.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Prehabilitation
Participants receive physiatry-led prehabilitation including exercise, nutrition, and mind/spirit practice during neoadjuvant systemic treatment
Surgery Preparation
Participants prepare for surgery following the prehabilitation program
Follow-up
Participants are monitored for safety and effectiveness after surgery
What Are the Treatments Tested in This Trial?
Interventions
- Physiatry-Led Cancer Prehabilitation
Trial Overview
The study tests a physiatry-led prehabilitation program during chemotherapy or other systemic treatments before surgery. This includes education, goal setting, interviews, personalized rehab plans, referrals to specialists if needed, supportive care, and surveys.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients attend a cancer physiatry consultation over 1 hour and receive an introduction to the home-based program, a starter prescription, and written prehabilitation education materials before the start of cycle 2 of NST. Patients then follow the provided starter prescription and attempt to meet aerobic exercise, resistance exercise, nutrition, and psychospiritual goals at home during and while off NST in the absence of unacceptable toxicity. Patients also attend additional cancer physiatry consultation follow-ups at 28 days and at 28 days after surgery. Additionally, patients receive resistance bands, sources for nutritional guidance, and practical tips and resources on study and may also receive tailored multidisciplinary referrals as needed.
Find a Clinic Near You
Who Is Running the Clinical Trial?
City of Hope Medical Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
Citations
Feasibility and Effects of Implementing Multimodal ... - PMC
These findings suggest that prehabilitation is both feasible and effective for patients with ovarian cancer, even during neoadjuvant chemotherapy.
2.
international-journal-of-gynecological-cancer.com
international-journal-of-gynecological-cancer.com/article/S1048-891X(24)22073-9/fulltextMultimodal Prehabilitation In Ovarian Cancer Patients ...
Prehabilitation patients had better tolerance to adjuvant chemotherapy, with significant fewer dose reductions (21% vs. 73%, p = 0.017) and a trend to less dose ...
3.
ovarian.org.uk
ovarian.org.uk/qi/case-studies/prehabilitation-pathways-for-patients-with-advanced-ovarian-cancer-belfast/Prehabilitation pathways for patients with advanced ...
Baseline assessments identified areas of concern, including frailty, reduced exercise capacity, malnutrition risk, and stress levels , nutrition, and psychology
Optimizing prehabilitation in gynecologic malignancies ...
Over 77 % of patients in the intervention group showed an improved walking ability before the abdominal surgery compared to a decrease in the control group.
5.
consultqd.clevelandclinic.org
consultqd.clevelandclinic.org/prehabilitation-program-aims-to-improve-outcomes-for-older-patients-with-ovarian-or-pancreatic-cancerStudy Explores the Benefit of Prehabilitation - Consult QD
Improving functional outcomes by 60% (measured during a six-minute walk. Reducing the rate of postoperative complications, 40% Improving ...
Physiatry-Led Cancer Prehabilitation During Neoadjuvant ...
This is a 12-question validated patient-reported outcome measure of function in outpatient cancer rehabilitation patients. Changes in the ...
a scoping review using realist principles | BMC Women's Health
Prehabilitation has been shown to reduce pulmonary and overall morbidity and improve post-operative gait, cardiovascular function and urinary ...
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