Lutein, Zeaxanthin, and Meso-Zeaxanthin for Skin Carotenoid Levels

This trial investigates the effectiveness of certain supplements—specifically Lutein, Zeaxanthin, and Meso-Zeaxanthin, nutrients often found in leafy greens—in improving skin carotenoid levels over 12 weeks. Participants will take either these supplements or a placebo (a pill with no active ingredients) to observe any noticeable differences. The goal is to determine if these supplements can naturally boost skin health. Ideal candidates are adults who do not smoke, have no major uncontrolled health issues, and are not currently using similar supplements. As an unphased trial, this study offers participants the chance to contribute to foundational research on enhancing natural skin health.

The trial information does not specify if you need to stop taking your current medications. However, if you are currently taking MacuHealth or similar supplements, you cannot participate.

Research has shown that lutein, zeaxanthin, and meso-zeaxanthin are generally safe for people. Studies found no harmful effects when taking high doses of lutein and zeaxanthin, up to 400 mg per kilogram of body weight per day, for 90 days. This suggests that the body can handle these substances well, even in large amounts.

Other research indicates that taking zeaxanthin orally is likely safe at doses up to 2 mg daily and possibly safe at higher doses, up to 10 mg daily. Most people can take it without issues.

Researchers are excited about using Lutein, Zeaxanthin, and Meso-Zeaxanthin for skin carotenoid levels because these compounds are naturally occurring antioxidants known for protecting skin against damage from UV light and pollution. Unlike typical skin treatments that might involve topical creams or chemical ingredients, these nutrients are taken as a dietary supplement, offering a unique inside-out approach to skin health. This method could enhance skin protection and health by increasing internal carotenoid levels, potentially leading to better skin resilience and appearance.

Research has shown that supplements containing lutein, zeaxanthin, and meso-zeaxanthin can increase carotenoid levels in the skin. In this trial, participants will receive either MacuHealth supplementation, which includes these nutrients, or a placebo. One study found that high doses of these nutrients improved skin carotenoid levels without causing serious side effects. Another study noted significant improvements in skin tone and brightness compared to a placebo. These findings suggest that the supplements might improve skin health by increasing carotenoid levels. Overall, the evidence supports their potential to enhance skin condition by boosting carotenoid concentration.⁶⁷⁸⁹¹⁰