Respiratory Muscle Training + Aerobic Exercise for Lung Health

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Roswell Park Cancer Institute
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine whether home-based respiratory muscle training (RMT) and aerobic exercise (AE) can enhance lung health in current or former smokers. Participants will use devices for breathing exercises or ride a stationary bike to strengthen their breathing muscles. The trial will compare different groups: some will perform RMT, others will engage in AE, and another group will receive education about both. It suits current or former smokers with a long smoking history, who have not recently experienced lung issues like pneumonia, and can follow instructions in English. As an unphased trial, this study offers a unique opportunity to contribute to research that may improve lung health strategies for smokers.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that these home-based exercise programs are safe for improving lung health?

Research has shown that respiratory muscle training (RMT) at home is generally safe and improves lung function without major side effects. RMT strengthens the muscles used for breathing, enhancing breathing ability and reducing tiredness.

Home-based aerobic exercise (AE) has also proven safe and effective, particularly for individuals with lung problems. It can improve lung function and overall fitness. These exercises are usually manageable, with few reports of serious issues.

Both RMT and AE have been studied in various conditions and are considered safe ways to improve lung health. Participants typically do not experience serious side effects, making these exercises a promising option for those seeking to enhance lung health at home.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it combines respiratory muscle training (RMT) and aerobic exercise (AE) to enhance lung health from home. Unlike typical treatments that might involve medication or hospital visits, this approach empowers individuals to improve their lung function through personalized, home-based exercises. The unique aspect here is the use of a device like Power Lung for RMT, which gradually increases resistance to strengthen respiratory muscles. Additionally, virtual supervision ensures participants stay safe and motivated, making this method both accessible and engaging. This innovative approach could pave the way for more convenient and effective lung health management.

What evidence suggests that this trial's treatments could be effective for improving lung health in current and former smokers?

Research shows that respiratory muscle training (RMT) at home can strengthen breathing muscles and help them work longer without fatigue. Studies have found that RMT can improve lung function and reduce symptoms like shortness of breath in people with chronic obstructive pulmonary disease (COPD). Additionally, past research suggests that RMT can enhance both breathing and physical abilities, especially when combined with other exercises. In this trial, participants in certain arms will engage in RMT sessions to evaluate these benefits.

For home-based aerobic exercise (AE), specific studies reviewed did not directly demonstrate its effectiveness. However, regular aerobic exercise is generally known to benefit heart and lung health. This suggests it might lower the risk of lung cancer by improving lung function in smokers. Participants in other arms of this trial will complete AE sessions to assess its impact on lung health. Together, RMT and AE could offer a promising approach to strengthening lung health in current and former smokers.678910

Who Is on the Research Team?

AD

Andrew D Ray

Principal Investigator

Roswell Park Cancer Institute

Are You a Good Fit for This Trial?

This trial is for current or former smokers aged 50 or older with at least a 20 pack-year smoking history, who can understand and follow instructions. People can't join if they have recent lung infections, uncontrolled heart problems, severe mental health issues, or are being treated for cancer.

Inclusion Criteria

I quit smoking within the last 15 years and smoked at least 20 pack-years.
Participant must be able to speak, read and comprehend English language
Understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure
See 3 more

Exclusion Criteria

I have had a lung infection or flare-up of a lung condition in the past 6 months.
Unwilling or unable to follow protocol requirements
I do not have any serious uncontrolled illnesses or conditions that would affect my participation.
See 2 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants complete home-based respiratory muscle training (RMT) and aerobic exercise (AE) programs for 12 weeks

12 weeks
5 days a week with weekly virtual supervision

Follow-up

Participants are monitored for safety and effectiveness after treatment

12 weeks
Optional follow-up at week 24

What Are the Treatments Tested in This Trial?

Interventions

  • Home-Based Aerobic Exercise
  • Home-Based Respiratory Muscle Training

Trial Overview

The study tests whether home-based breathing muscle training using a handheld device and aerobic exercise on a stationary bike can improve lung health in current and former smokers. Participants do these exercises at home as part of the program.

How Is the Trial Designed?

5

Treatment groups

Experimental Treatment

Active Control

Group I: Cohort B Arm IV (RMT)Experimental Treatment6 Interventions
Group II: Cohort A Arm II (AE)Experimental Treatment7 Interventions
Group III: Cohort A Arm I (RMT)Experimental Treatment7 Interventions
Group IV: Cohort B Arm V (AE and RMT education)Active Control5 Interventions
Group V: Cohort A Arm III (AE and RMT education)Active Control6 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Roswell Park Cancer Institute

Lead Sponsor

Trials
427
Recruited
40,500+

Citations

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