Morning Light Therapy for Inflammatory Bowel Disease

HS
Overseen ByHyder Said
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether morning light therapy can help adults with ulcerative colitis, a type of inflammatory bowel disease, who also have trouble sleeping. The aim is to determine if this therapy can improve sleep quality and reduce inflammation. Participants will use morning light therapy for an hour each day while tracking their sleep and symptoms. The trial seeks individuals with ulcerative colitis experiencing active inflammation and poor sleep. As an unphased trial, it offers a unique opportunity to explore a novel approach to managing symptoms and improving quality of life.

Will I have to stop taking my current medications?

You may need to stop taking certain medications, especially those affecting sleep or the autonomic nervous system, like beta-blockers, benzodiazepines, and sleep medications. If you regularly use these, you might need a 4-week period without them before joining the study.

What prior data suggests that morning light therapy is safe for patients with ulcerative colitis?

Research has shown that morning light therapy (MLT) is generally safe and well-tolerated for people with inflammatory bowel disease (IBD), including ulcerative colitis (UC). Studies have found MLT to be a practical and acceptable treatment option. No major reports of serious side effects have emerged from this therapy. Most patients manage the therapy without significant problems, suggesting it could be a good choice for those seeking alternative ways to manage their symptoms.12345

Why are researchers excited about this trial?

Unlike the standard treatments for ulcerative colitis, which often include medications like aminosalicylates, corticosteroids, or immunosuppressants, morning light therapy offers a novel, non-drug approach. Researchers are excited about this treatment because it harnesses natural light exposure to potentially regulate the body's circadian rhythms and reduce inflammation. This could provide a gentler alternative with fewer side effects, offering hope for those who struggle with the side effects of traditional medications.

What evidence suggests that morning light therapy might be an effective treatment for ulcerative colitis?

Research suggests that morning light therapy, which participants in this trial will receive, can help individuals with inflammatory bowel disease (IBD), such as ulcerative colitis, by improving symptoms and reducing disease activity. Morning light resets the body's internal clock, potentially enhancing sleep and reducing inflammation. Studies have shown that this therapy eases symptoms by aligning sleep patterns with natural light cycles. As a result, patients might experience less inflammation and better overall health. Although more research is needed, early findings are encouraging.12356

Who Is on the Research Team?

HS

Hyder Said

Principal Investigator

Icahn School of Medicine at Mount Sinai

RH

Robert Hirten, MD

Principal Investigator

Icahn School of Medicine at Mount Sinai

Are You a Good Fit for This Trial?

Adults with ulcerative colitis, poor sleep quality, and active inflammation can join this trial. They must not be pregnant or lactating, have a pacemaker/defibrillator, work night shifts, use drugs/marijuana recently, have serious health issues like heart attack/stroke/failure of kidneys or liver/infections, take certain medications affecting the nervous system/sleep/IBD treatment changes in last 3 months. Those with recent surgery or untreated sleep apnea are excluded.

Inclusion Criteria

I have ulcerative colitis with signs of inflammation.

Exclusion Criteria

Known pregnancy or currently lactating women
Patients with pacemaker or defibrillators
Comprehension of the English language not adequate to understand the questionnaires
See 14 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week
1 visit (in-person)

Lead-in

Participants obtain baseline circadian-related labs, complete symptom-related surveys, and use a wearable device continuously to obtain baseline sleep-wake data

1 week

Treatment

Participants undergo one hour of morning light therapy while wearing wearable devices continuously and completing daily symptom surveys

4 weeks

Follow-up

Participants obtain post-intervention circadian and inflammatory assessments and complete the same symptom-related surveys

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Morning Light Therapy
Trial Overview The study tests if morning light therapy (MLT) for one hour daily over four weeks improves sleep and reduces inflammation in ulcerative colitis patients with disrupted circadian rhythms. Participants will wear devices to track sleep-wake patterns and complete surveys before and after MLT while their inflammatory markers are monitored.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Adult patients with Ulcerative Colitis (UC)Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Icahn School of Medicine at Mount Sinai

Lead Sponsor

Trials
933
Recruited
579,000+

Citations

Morning light treatment for inflammatory bowel diseaseMorning light treatment, which advances and stabilizes circadian timing, may have the potential to improve IBD symptoms and disease activity, ...
A Pilot Study Looking at Changes in Sleep Timing and IBD ...This research study is testing whether changes in sleep timing and morning light treatment may have an impact on symptoms related to inflammatory bowel disease.
3.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/38778264/
Morning light treatment for inflammatory bowel diseaseMorning light treatment, which advances and stabilizes circadian timing, may have the potential to improve IBD symptoms and disease activity, ...
Impact of Morning Light Therapy in IBDThe pilot study will focus on the effects of morning light therapy (MLT) in adult patients with ulcerative colitis (UC) who have evidence of ...
(PDF) Morning light treatment for inflammatory bowel diseaseMorning light treatment, which advances and stabilizes circadian timing, may have the potential to improve IBD symptoms and disease activity, ...
A Pilot Study Looking at Changes in Sleep Timing and IBD ...This research study is testing whether changes in sleep timing and morning light treatment may have an impact on symptoms related to ...
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