Essential Oil Blend for Immune Support
(OGS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This randomized, double-blind, placebo-controlled clinical trial will evaluate the safety and efficacy of an essential oil-based product system for immune support in healthy adolescents and adults aged 18-45 years. Participants will be randomized to receive aromatic, topical, internal, or combined use of the investigational product or matching placebo for 30 days.
The aromatic intervention consists of overnight diffusion, the topical intervention consists of diluted application to specified areas prior to bedtime, and the internal intervention consists of oral capsule administration twice daily. Study visits will occur at baseline and at the end of the 30-day intervention period.
Primary outcomes include changes in immune-related biomarkers, including complete blood count, comprehensive metabolic panel, salivary immunoglobulin A (IgA), and inflammatory cytokines (IL-6, TNF-α, IL-10). Epigenetic markers will also be evaluated. Secondary outcomes include validated subjective assessments of immune status and overall well-being, as well as evaluation of safety and tolerability.
The study includes an adaptive design with interim analysis to assess enrollment and study continuation parameters.
Who Is on the Research Team?
Nicole Stevens, PhD
Principal Investigator
DoTERRA International LLC.
Are You a Good Fit for This Trial?
This trial is for healthy men and women aged 18-45 who can attend study visits, follow instructions, and avoid using essential oils outside the study. People with allergies to essential oils, certain health conditions (like asthma or heart disease), tobacco users, pregnant or breastfeeding women, and those recently using essential oils without a washout period cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive the investigational essential oil-based product system or placebo for 30 days through aromatic, topical, internal, or combined use
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Essential Oil Blend
Trial Overview
The study tests an essential oil blend used in different ways—aromatic (diffused overnight), topical (applied to skin before bed), internal (oral capsules twice daily), or combinations—compared to a placebo. Participants are randomly assigned treatments for 30 days in a double-blind design.
How Is the Trial Designed?
8
Treatment groups
Experimental Treatment
Placebo Group
Participants assigned to this arm will apply a diluted preparation of the investigational essential oil blend topically prior to bedtime daily for 30 days.
Participants assigned to this arm will ingest capsules containing the investigational essential oil blend twice daily with meals for 30 days.
Participants assigned to this arm will use aromatic diffusion, topical application, and oral capsule administration of the investigational essential oil blend daily for 30 days.
Participants assigned to this arm will diffuse the investigational essential oil blend overnight (approximately 8 hours) for 30 days according to a standardized protocol.
Participants assigned to this arm will diffuse a placebo preparation overnight (approximately 8 hours) for 30 days using the same protocol as the active aromatic arm.
Participants assigned to this arm will apply a placebo preparation topically prior to bedtime daily for 30 days using the same protocol as the active topical arm.
Participants assigned to this arm will ingest placebo capsules twice daily with meals for 30 days.
Participants assigned to this arm will use placebo preparations for aromatic diffusion, topical application, and oral capsule administration daily for 30 days.
Find a Clinic Near You
Who Is Running the Clinical Trial?
dōTERRA International
Lead Sponsor
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