Photobiomodulation for In Vitro Fertilization

(HELIOS-A Trial)

This trial tests a gentle light therapy called photobiomodulation (PBM) to determine its effectiveness in improving outcomes during in vitro fertilization (IVF). As women age, the energy production in their egg cells declines, which can hinder embryo development. PBM uses red light to boost cellular energy, potentially enhancing embryo growth and pregnancy success. Participants undergoing IVF with their own eggs might be suitable, especially if they have at least two eggs available for the study. As an unphased trial, this study provides a unique opportunity to explore innovative treatments that could enhance IVF success.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that photobiomodulation (PBM), a gentle light therapy, is generally safe for people. Studies have found that using red and near-infrared light in PBM can boost cellular energy without causing harm. For example, one study discovered that this light increased energy production in sperm cells without any damage. Another study demonstrated improved fertility outcomes, indicating safety for reproductive health. Overall, these findings suggest PBM is a safe treatment option, with no major side effects reported.¹²³⁴⁵

Photobiomodulation is unique because it uses light therapy to potentially enhance the success of in vitro fertilization (IVF), a process that typically relies on hormonal treatments and lab techniques to assist reproduction. Unlike standard IVF treatments, which focus primarily on manipulating the biological environment chemically or physically, photobiomodulation introduces a non-invasive approach that leverages light to stimulate cellular activity and improve egg quality. Researchers are excited about this technique because it represents a novel mechanism of action that could increase the chances of successful fertilization and implantation without additional drugs or invasive procedures.

Research has shown that photobiomodulation (PBM), a type of red light therapy, may improve fertility. In one study, 46.7% of women who received PBM had higher pregnancy rates compared to those who did not. Another study found that 66% of participants became pregnant within one to three months after PBM treatment. This therapy appears to boost energy production in cells, which is crucial for developing healthy eggs and embryos. Studies on animals and early clinical trials suggest that PBM can enhance embryo growth and increase the number of healthy early-stage embryos, known as blastocysts. In this trial, participants will be randomized into two groups: one group will receive PBM as part of their IVF treatment, while the other group will not. These findings suggest that PBM could be a promising addition to fertility treatments like in vitro fertilization (IVF).¹⁴⁵⁶⁷