Intraosseous Antibiotics for Peri-Implantitis

(IOAOI Trial)

This trial explores the safety and effectiveness of delivering antibiotics directly into the bone for individuals with infections around their osseointegration implants. Osseointegration connects a prosthetic limb directly to the bone. The study includes two groups: one group will be observed, while the other will receive bone-delivered antibiotics if surgery becomes necessary. Suitable participants have undergone osseointegration after amputation and now face potential infection at the surgical site.

As an unphased trial, this study provides a unique opportunity to contribute to innovative treatment approaches for infection management.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that using antibiotics directly in the bone during dental procedures can help prevent infections. Understanding the safety of this method for patients is crucial. One study found that dental implants treated with clindamycin, an antibiotic, were more likely to fail compared to those treated with amoxicillin. This suggests that the choice of antibiotic can impact treatment success.

Another review indicated that administering antibiotics before a dental procedure can help implants last longer. Specifically, taking a single dose of antibiotics before the procedure reduced the chance of implant failure. However, routinely giving antibiotics to all patients receiving dental implants does not always prevent failures or infections in healthy individuals.

Researchers are excited about the intraosseous antibiotic delivery technique for peri-implantitis because it offers a targeted approach by delivering antibiotics directly into the bone, right where the infection is happening. Unlike traditional treatments that often rely on oral antibiotics or surgical debridement, this method aims to enhance the effectiveness of the medication by concentrating it at the infection site, potentially reducing the need for more invasive procedures. This focused delivery could lead to faster healing and less systemic exposure to antibiotics, which is a significant advantage over current methods.

Research has shown that antibiotics during dental implant procedures can reduce the risk of implant failure. One study found that antibiotics significantly lowered this risk. Another review demonstrated that taking antibiotics before the procedure resulted in fewer failures compared to not using them. While antibiotics aren't always necessary for routine dental implants, they are recommended when there's a risk of infection, such as inflammation around an implant. In this trial, one group will receive intraosseous antibiotics for osseointegration, applying antibiotics directly to the bone to manage infections during implant surgeries. Another group will be observational, consisting of patients who do not require surgery for infection.¹²³⁶⁷