Hamstring Strengthening for Hypermobility Syndrome

This trial tests whether strengthening the hamstring muscles can help individuals with hypermobility spectrum disorders (HSD) or hypermobile Ehlers-Danlos syndrome (hEDS) by reducing knee joint looseness and improving pain levels. Participants will attend exercise classes twice a week for 12 weeks, focusing on specific hamstring exercises, including progressive resistance exercise with an emphasis on eccentric hamstring loading. The trial seeks individuals diagnosed with HSD or hEDS who are cleared to exercise. This opportunity may suit those experiencing joint looseness and officially diagnosed with these conditions. As an unphased trial, this study offers a unique chance to contribute to understanding how exercise can benefit those with HSD or hEDS.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Previous studies have shown that exercises focusing on lengthening the hamstring muscles are safe and well-tolerated. Research indicates that these exercises can safely begin shortly after a hamstring injury. For instance, athletes started intense hamstring exercises soon after injury without issues, suggesting general safety.

Moreover, other studies found that these exercises do not harm individuals with very flexible joints. In fact, they improved outcomes for those individuals. This is promising for participants with hypermobility, as it suggests the exercises are likely safe and beneficial.

Unlike standard treatments for hypermobility syndrome that often focus on general physical therapy or pain management, this new approach emphasizes progressive resistance exercise with eccentric hamstring loading. This technique specifically targets muscle strengthening in a controlled manner, which may improve stability and reduce injury risk. Researchers are excited because this method offers a targeted way to bolster the hamstrings, potentially enhancing joint support and overall mobility more effectively than traditional methods.

Research has shown that certain hamstring exercises can improve muscle strength and flexibility. In this trial, participants will engage in a 12-week supervised lower limb strengthening program focused on eccentric hamstring loading. For individuals with hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS), these exercises have been adjusted to effectively strengthen the legs. Studies suggest that these exercises can stabilize joints by reducing looseness. They also help prevent injuries by enhancing muscle control and strength. Additionally, evidence suggests that these exercises could reduce pain and improve overall movement.¹²³⁴⁶