Cascade Testing for High Cholesterol
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to evaluate the effectiveness of two models of cascade testing in identifying at-risk family members of individuals diagnosed with familial hypercholesterolemia (FH).
Who Is on the Research Team?
Elisa J. Houwink, MD, PhD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for adults (18+) diagnosed with familial hypercholesterolemia (FH) who have at least one close relative willing to participate and use email. Their relatives, aged 1 or older, can join if they are first- or second-degree family members and able to give consent. People who've already done structured cascade testing can't join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Data Collection
Collection of demographics and FH-related history via REDCap; LDL-C values abstracted from EMR
Intervention
Relatives in the intervention arm receive FMTT sputum kits and educational materials; genetic testing facilitated
Control
Relatives may seek genetic testing independently; no structured outreach provided
Follow-up
Participants receive surveys at 1, 3, and 12 months; follow-up for positive genetic findings
What Are the Treatments Tested in This Trial?
Trial Overview
The study compares two ways of reaching out to families of people with FH—standard care versus a method called cascade testing—to see which better identifies relatives at risk for high cholesterol. Participation involves electronic communication and consent.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Patients and relatives will receive outreach in the form of direct or indirect contact
Patients will receive standard of care support
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
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