Haelan 951 for Menopause

(H951-MENO Trial)

This trial aims to assess how a fermented soy product, Haelan 951, affects menopause symptoms such as hot flashes and sleep quality. Researchers seek data from women who have experienced menopause-related symptoms, like frequent hot flashes, for at least three months. Participants will take Haelan 951 daily for 30 days and report their experiences using a smartphone app. Women who have gone through menopause or are in transition, live in the Kansas City area, and can manage symptoms without starting new treatments might be suitable candidates. As an unphased trial, this study provides a unique opportunity to contribute to understanding menopause symptom management.

If you are currently using hormone replacement therapy (HRT) or menopause-related supplements, you will need to stop them at least 30 days before starting the trial. If you are on a stable regimen of menopause-related supplements for at least 3 months, you can continue them unchanged. Other medications that might interact with soy-derived foods may also need to be adjusted.

Research has shown that Haelan 951, a fermented soy food, has been studied for its effects on various conditions. In these studies, using Haelan 951 at levels below 8% did not cause any harmful effects, suggesting it is generally safe at these amounts. As a food rather than a drug, Haelan 951 may have a favorable safety profile.

Although detailed information on side effects is limited, some individuals have reported mild and temporary digestive issues. Such effects are common when trying new dietary products.

Unlike the standard hormone replacement therapies for menopause, Haelan 951 is a fermented soy product that offers a more natural approach to managing symptoms. Researchers are excited about Haelan 951 because it leverages the benefits of soy, which contains natural compounds called phytoestrogens that can mimic estrogen in the body. This treatment is unique because it is consumed as a conventional food product, making it potentially more accessible and with fewer side effects than synthetic hormone treatments. Additionally, the use of wearable devices and electronic patient-reported outcomes in monitoring its effects represents a modern, patient-friendly approach to treatment.

Research has shown that soy isoflavones, the main ingredient in Haelan 951, can help reduce menopause symptoms like hot flashes. One study found that soy isoflavones decreased the severity of hot flashes by about 26% compared to a placebo. Other studies indicate that isoflavones can also reduce major menopause symptoms, especially those related to temperature changes, such as hot flashes and night sweats. While results can vary, this evidence suggests that Haelan 951, which participants in this trial will receive, may improve life for women experiencing menopause.³⁵⁶⁷⁸