High Intensity Interval Training for Hodgkin's Lymphoma Survivors

Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: St. Jude Children's Research Hospital
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores the feasibility of a 12-week high-intensity interval training (HIIT) program for individuals who survived Hodgkin's lymphoma in their youth. The goal is to determine if HIIT can improve fitness, body health, and overall physical activity after treatment. It is ideal for those who had Hodgkin's lymphoma, completed treatment within the last two years, and are ready for physical exercise. Participants will engage in 25-minute HIIT sessions three times a week, each including warm-ups and cool-downs. The trial seeks survivors who are not currently engaged in intense workouts or excessive exercise.

As an unphased trial, this study provides a unique opportunity to contribute to research that could enhance post-treatment recovery and fitness.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that this high intensity interval training program is safe for Hodgkin's lymphoma survivors?

Research shows that high-intensity interval training (HIIT) is generally safe for cancer survivors. Studies indicate that people who have undergone cancer treatment can perform HIIT with few or no negative effects. This exercise involves short bursts of intense activity followed by brief rest periods. Previous trials found that cancer survivors usually handle these workouts well, with few reports of side effects. This suggests that the HIIT program in this trial is likely safe for Hodgkin's lymphoma survivors.12345

Why are researchers excited about this trial?

Researchers are excited about using High Intensity Interval Training (HIIT) for Hodgkin's Lymphoma survivors because it offers a non-pharmacological approach to improving health and fitness. Unlike standard treatments for Hodgkin's Lymphoma, which often include chemotherapy and radiation, HIIT focuses on enhancing cardiovascular health and physical strength without additional medication. The high-intensity, short-duration workouts are designed to maximize heart health and recovery, potentially leading to improved quality of life for survivors. This exercise regimen is unique in its ability to target fitness levels quickly, with sessions lasting just 25 minutes, making it an efficient option for those looking to regain their strength post-treatment.

What evidence suggests that high intensity interval training is effective for Hodgkin's lymphoma survivors?

Research has shown that High Intensity Interval Training (HIIT) benefits cancer survivors, including those with Hodgkin's lymphoma. Studies have found that HIIT can enhance quality of life and physical fitness. For instance, cancer patients in a HIIT program reported improved quality of life. Participation rates in these programs range from 54% to 100%. In this trial, participants in the HIIT Intervention Group will complete a 12-week HIIT program. Overall, HIIT appears promising for helping Hodgkin's lymphoma survivors improve their physical health and well-being.12367

Who Is on the Research Team?

AB

Amy Berkman, MD

Principal Investigator

St. Jude Children's Research Hospital

Are You a Good Fit for This Trial?

This trial is for survivors of childhood, adolescent, and young adult Hodgkin lymphoma who finished treatment within the last 24 months. It's designed to see if they can participate in a high-intensity exercise program.

Inclusion Criteria

Participant has been medically cleared to participate in physical activity
Participant verbalizes understanding of directions for use of the web-based platform on the study provided iPad and heart rate monitor
I was diagnosed with Hodgkin lymphoma when I was between 10 and 25 years old.
See 2 more

Exclusion Criteria

Participant reports currently participating in HIIT training or >420 minutes per week of moderate to vigorous physical activity
My condition has worsened after initial improvement.
I have been diagnosed with acute heart failure.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo baseline assessments including exercise testing, body composition, autonomic function, and blood biomarkers

1 week
1 visit (in-person)

Treatment

Participants complete a 12-week HIIT program with three 25-minute sessions per week, delivered via a secure web-based platform with live supervision

12 weeks
Remote sessions

Post-intervention Assessment

Participants undergo post-intervention assessments to evaluate changes in health outcomes

1 week
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the intervention

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • High Intensity Interval Training (HIIT)
Trial Overview The study tests a 12-week High Intensity Interval Training (HIIT) program. It aims to check how feasible it is for participants and measure its effects on fitness, body composition, physical function, response to exercise, nerve health, aging markers, and activity levels.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: HIIT Intervention GroupExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

St. Jude Children's Research Hospital

Lead Sponsor

Trials
451
Recruited
5,326,000+

Citations

Feasibility of High Intensity Interval Training in Survivors ...This pilot study evaluates the feasibility of a 12-week high intensity interval training (HIIT) program in survivors of childhood, adolescent, ...
Effectiveness of HIIT in Cancer Patients & Survivors: ReviewQoL showed positive results although with some controversy. Adherence to HIIT intervention was high, ranging from 54% to 100%.
Feasibility of High Intensity Interval Training in Survivors of ...This pilot study evaluates the feasibility of a 12-week high intensity interval training (HIIT) program in survivors of childhood, ...
High Intensity Interval Training for Hodgkin's Lymphoma ...This pilot study evaluates the feasibility of a 12-week high intensity interval training (HIIT) program in survivors of childhood, adolescent, ...
Effects of HIIT on Quality of Life in CLL: Pilot StudyScores for FWB improved following HIIT+RT (21.7 ± 3.4 to 23.9 ± 3.2; ES = 1.38) compared to controls (25.7 ± 2.2 to 25.7 ± 2.3). The HIIT+RT group experienced ...
The impact of high intensity interval training in a diverse ...We observed meaningful improvements in body composition, HbA1c and quality of life over 12 weeks among cancer survivors participating in a high-intensity ...
Effects of high-intensity interval training on health-related ...The purpose of this study was to investigate the effects of a 12-week HIIT and RT (HIIT+RT) intervention on HRQOL in adults with treatment naïve CLL.
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