Exercise Program for Cancer

(DEFEND Trial)

This trial aims to determine if an exercise program delivered via video calls can help cancer patients manage treatment side effects like fatigue and loss of strength. Participants will engage in virtual sessions with trained staff to guide resistance exercises and will receive guidance for aerobic exercises to perform independently. This distance-based exercise program seeks cancer patients who are beginning chemotherapy for at least ten weeks, are employed full-time, can walk for six minutes, and are not currently involved in competitive sports or rigorous exercise programs.

As an unphased trial, this study provides a unique opportunity for patients to explore innovative ways to enhance their well-being during treatment.

The trial information does not specify whether you need to stop taking your current medications. It focuses on an exercise program for cancer patients, so it's best to discuss your medications with your doctor.

Research has shown that exercise is generally safe for cancer patients. A review of studies found that exercise can reduce unwanted side effects and improve well-being for people with cancer, lowering risks and enhancing quality of life. Another study found that exercise significantly reduced the risk of death among cancer patients. Several studies indicate that regular exercise also improves physical function and quality of life.

Researchers are excited about the Exercise Program for Cancer because it offers a novel approach to supporting cancer patients during treatment. Unlike traditional cancer therapies that focus solely on medication and surgery, this program incorporates distance-based exercise, blending supervised resistance training and unsupervised aerobic sessions. This approach aims to enhance patients' physical resilience and overall well-being while undergoing chemotherapy, potentially reducing treatment-related side effects. Additionally, the use of adjustable-weight dumbbells and accelerometers tailors the exercise regimen to each patient's capacity, promoting a personalized and proactive strategy in cancer care.

Research has shown that exercise can enhance the quality of life and health for people with cancer. Studies have found that exercise reduces tiredness and boosts physical fitness, addressing common challenges faced by cancer patients during treatment. One study discovered that online, home-based exercise programs can improve body shape and physical health over time. Additionally, exercise has been linked to lower death rates in cancer patients, potentially extending their lives. This trial will evaluate a distance-based exercise program, which shows some promise, although previous studies suggest it hasn't significantly increased physical activity among cancer survivors. Overall, exercise can be a valuable component of cancer care.¹²⁴⁶⁷