Creatine for Acute Kidney Injury

This trial aims to determine if taking creatine monohydrate for a week can reduce inflammation, lower the risk of acute kidney injury, and improve cognitive function during exercise in hot conditions. Participants will receive either creatine monohydrate (a dietary supplement) or a placebo (a substance with no active effect) and then exercise in a heated environment. The study seeks active individuals who exercise regularly and do not have major health issues like heart or kidney problems. As an unphased trial, this study offers participants the chance to contribute to scientific understanding and potentially benefit from creatine monohydrate's effects.

Yes, you may need to stop taking certain medications or supplements that could affect your body's temperature regulation, heart rate, kidney function, or blood pressure during exercise, such as NSAIDs (non-steroidal anti-inflammatory drugs).

Research has shown that creatine monohydrate is generally safe for healthy individuals. Studies have found no major negative effects on kidney function when used as directed. Specifically, research consistently indicates no harm to kidney health when creatine is taken in recommended amounts. Some studies mention that it might temporarily increase a blood marker called serum creatinine, but this does not indicate actual kidney damage. Most people tolerate creatine well, and it does not cause significant side effects in healthy users. However, individuals with existing kidney issues should exercise caution, as creatine might worsen these problems. Overall, creatine supplements appear safe for those without kidney concerns.¹²³⁴⁵

Researchers are excited about using creatine monohydrate for acute kidney injury because it offers a unique approach compared to traditional treatments. Unlike standard care options, which often focus on managing symptoms and preventing further damage, creatine monohydrate aims to improve cellular energy production. This could potentially enhance the kidney's resilience during injury by supporting ATP regeneration, a crucial energy source for cells. Additionally, the quick administration schedule—starting with a higher dose for just a week—might lead to faster results, making it a promising option for acute situations.

Research has shown that taking creatine can temporarily raise creatinine levels in the blood. While this might appear to stress the kidneys, it typically does not cause harm. Studies have found that normal amounts of creatine do not damage kidney function in healthy individuals. Some reports advise caution because a few cases have linked high doses of creatine to kidney problems, but these instances are rare. Overall, when used properly, creatine is considered safe for the kidneys. In this trial, participants will receive either creatine monohydrate or a placebo (maltodextrin) to assess its effects on acute kidney injury.¹⁴⁵⁶⁷