Transcranial Magnetic Stimulation for Hormonal Modulation in Healthy Women

This trial explores whether Transcranial Magnetic Stimulation (TMS), a non-invasive procedure using magnetic fields to stimulate nerve cells, can influence hormone levels in healthy women. It specifically examines hormones like Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), which are crucial in the menstrual cycle. Participants will receive either active TMS or a sham (placebo-like) treatment. Women with regular menstrual cycles in the luteal phase (second half of the menstrual cycle) may be suitable for this trial. As an unphased trial, this study provides a unique opportunity to advance scientific understanding of TMS and its potential effects on hormone regulation.

Yes, you will need to stop taking any medications that affect the central nervous system, such as antidepressants, antipsychotics, or hormone therapies, to participate in this trial.

Research has shown that Transcranial Magnetic Stimulation (TMS) is generally safe. Studies have found that TMS is well-tolerated for treating conditions like major depressive disorder, with side effects usually being mild, such as slight headaches or scalp discomfort.

One study found that TMS could affect hormone levels, such as thyroid hormones, in both depressed and healthy adults, but these changes were not harmful. Another study examined TMS effects on hormone levels in men with consciousness disorders and found no significant side effects.

Transcranial Magnetic Stimulation (TMS) is unique because it uses magnetic fields to stimulate specific areas of the brain, potentially influencing hormone levels. Unlike traditional hormonal treatments that might involve medications or invasive procedures, TMS is non-invasive and focused directly on brain activity. Researchers are excited about this method because it offers a novel way to modulate hormones without the side effects associated with systemic treatments, paving the way for more targeted, personalized healthcare.

Research shows that Transcranial Magnetic Stimulation (TMS) might influence hormone levels, such as Luteinizing Hormone (LH) and Follicle-stimulating hormone (FSH). Studies have found that TMS can change brain activity, potentially leading to changes in hormone levels. Some research suggests that women, particularly those with high estradiol levels (a type of estrogen), respond more to TMS. This trial will compare an active TMS treatment arm with a sham arm, where no magnetic pulses are applied. The treatment sends magnetic pulses to specific brain areas, which might mimic natural hormone signals. While research continues, these findings suggest TMS could help adjust hormone levels in healthy women.¹⁶⁷⁸⁹