25 Participants NeededMy employer runs this trial

Sham TMS for Healthy Subjects

Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: University of California, Davis
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how a person's expectations about treatment can affect mood, motivation, and reactions to daily rewards. Participants will undergo an accelerated sham version of transcranial magnetic stimulation (TMS), meaning no actual brain stimulation will occur. The study examines whether different treatment schedules alter these expectations and their effects. Young English-speaking individuals aged 15-25, without any metal in their bodies that could interfere with MRI scans, may be suitable for this trial. As an unphased trial, it offers participants the chance to contribute to understanding how expectations influence treatment outcomes.

Do I have to stop taking my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.

Why are researchers excited about this trial?

While most treatments for neurological conditions rely on active interventions like medication or stimulation, sham Transcranial Magnetic Stimulation (TMS) offers a unique angle by providing no active stimulation at all. Researchers are excited about this trial because it helps distinguish the psychological effects of receiving treatment from the physiological effects of actual TMS. This can deepen our understanding of how expectations and beliefs impact treatment outcomes, potentially leading to more effective and targeted therapies in the future.

Are You a Good Fit for This Trial?

This trial is for healthy young people ages 15-25 who can speak English and are able to give consent (or assent if under 18).

Inclusion Criteria

I can give my consent to participate.
I am between 15 and 25 years old.
I speak English.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Baseline Assessment

Participants complete baseline clinical assessments and an MRI session

1 week
1 visit (in-person)

Treatment

Participants undergo five days of accelerated sham TMS (no active brain stimulation is delivered)

1 week
5 visits (in-person)

Follow-up

Participants complete post-treatment MRI and follow-up assessments at 1 week and 4 weeks

4 weeks
2 visits (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Transcranial Magnetic Stimulation Sham

Trial Overview

The study tests how expectations about treatment affect mood and motivation. Participants receive a placebo version of accelerated transcranial magnetic stimulation (TMS), meaning no real brain stimulation is given.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Open label shamExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, Davis

Lead Sponsor

Trials
958
Recruited
4,816,000+