Mango for Gut Health
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how eating mangoes affects gut health in people with prediabetes. Researchers aim to determine if consuming 1.5 cups of mango daily for 12 weeks can alter specific gut health markers. Participants will undergo two phases: one with mango consumption and one without, to compare results. Only individuals from a previous mango study (NCT06159543) are eligible to join. As an unphased trial, this study provides a unique opportunity to contribute to understanding the potential health benefits of mangoes.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that the mango intervention is safe for individuals with prediabetes?
Research shows that eating mango is generally safe for most people. Studies have found that mangoes benefit gut health by containing compounds that aid digestion and support healthy gut bacteria. Some research even suggests that mangoes can increase levels of certain beneficial acids in the gut.
However, mangoes are high in sugars like sucrose and fructose, which might cause some people to feel gassy or bloated. These side effects are usually mild and uncommon.
Overall, evidence suggests that adding mango to the diet is well-tolerated. Most people should not experience major issues, but it's always good to monitor how one feels after eating them.12345Why are researchers excited about this trial?
Unlike traditional treatments for gut health, which often involve probiotics, fiber supplements, or medications, this approach uses mango as a natural dietary addition. Mangoes are rich in fiber, antioxidants, and bioactive compounds, which may support gut health by promoting beneficial gut bacteria and reducing inflammation. Researchers are excited about this treatment because it offers a simple, tasty, and potentially effective way to improve gut health without the need for pills or supplements. Plus, adding mango to the diet could provide additional nutritional benefits beyond gut health.
What evidence suggests that mango might be an effective treatment for gut health in individuals with prediabetes?
Research has shown that eating mangoes can improve gut health. Consuming 100 grams of fresh mango daily for four weeks increased the variety of gut bacteria, which is crucial for a healthy gut. Mangoes are rich in natural compounds called polyphenols, which interact well with gut bacteria and may help reduce inflammation. Another study found that eating mangoes increased the production of short-chain fatty acids (SCFAs), beneficial substances made by gut bacteria. In this trial, one group of participants will add mango to their habitual diet, while another group will continue their habitual diet without mango. These findings suggest that adding mango to the diet may support better gut health and reduce inflammation in the body.45678
Who Is on the Research Team?
Celine Heskey, DrPH
Principal Investigator
Loma Linda University
Are You a Good Fit for This Trial?
This trial is for men and women aged 40-60 with prediabetes who already took part in the earlier NCT06159543 study. Participants must have completed that previous trial.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume 1.5 cups of mango per day for 12 weeks as part of their habitual diet
Control
Participants refrain from consuming mangoes for 12 weeks while continuing their habitual diet
Follow-up
Participants are monitored for changes in gut permeability markers and short chain fatty acid production
What Are the Treatments Tested in This Trial?
Interventions
- Mango
Trial Overview
The study tests if eating 1.5 cups of fresh mango daily for 12 weeks affects gut health markers, like certain blood proteins and gut bacteria byproducts, compared to periods without mango. Each participant tries both phases (with and without mango).
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
In NCT06159543 participants were asked to consume 1.5 cups of mango per day for 12 weeks as part of their habitual diet.
In NCT06159543 participants were asked to refrain consuming mangoes for 12 weeks while continuing their habitual diet.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Loma Linda University
Lead Sponsor
Citations
The effects of fresh mango consumption on gut health ... - PMC
This study found that daily consumption of 100 g fresh mango increased the diversity of the gut microbiome after 4 weeks, with the greatest ...
Mango (Mangifera indica L.) Polyphenols
This review provides an overview of interactions of mango polyphenols with the intestinal microbiome, associated health benefits and underlying mechanisms.
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prnewswire.com
prnewswire.com/news-releases/new-study-mangos-help-promote-gut-health-300659995.htmlNew Study: Mangos Help Promote Gut Health
Mango supplementation significantly improved constipation status (stool frequency, consistency and shape) and increased short chain fatty acids ...
Mango (Mangifera indica L.) Polyphenols: Anti- ...
This review provides an overview of interactions of mango polyphenols with the intestinal microbiome, associated health benefits and underlying mechanisms.
Mango (Mangifera indica L.) polyphenols reduce IL-8, GRO ...
Mango polyphenols possess anti-inflammatory and microbiome-modulatory activities and may improve symptoms of IBD, reduce biomarkers for inflammation and ...
Effect of Mango on Gut Microbiota and Metabolic Health
Mango is rich in bioactive compounds such as dietary polyphenols and carotenoids, which may explain its beneficial effect on health. Polyphenols accumulate in ...
Mango Supplementation Modulates Gut Microbial ...
Our findings revealed that mango supplementation in HF diet-fed mice prevented the loss of beneficial gut bacteria, specifically Bifidobacteria, Akkermansia, ...
The effects of fresh mango consumption on gut health and ...
There was a slight increase in the amount of bowel movement with mango consumption, but no significant findings for frequency, consistency, ...
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