Exercise for Blood Sugar Control
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how different types of exercise affect blood sugar levels in non-diabetic and pre-diabetic adults. Participants will engage in two exercise routines: five days of moderate exercise and one session of high-intensity interval training (HIIT). The study examines the impact of these exercises on blood sugar levels to determine which is more effective in maintaining stability. Ideal candidates are those without diabetes but with slightly elevated blood sugar levels, who can perform both types of exercise and wear a continuous glucose monitor for 11 days. As an unphased trial, this study allows participants to contribute to valuable research on exercise and blood sugar management.
What prior data suggests that these exercise protocols are safe for blood sugar control?
Research has shown that both High Intensity Interval Training (HIIT) and moderate intensity aerobic exercise are generally safe and well-tolerated by adults, including those at risk for or with type 2 diabetes.
HIIT can enhance heart and lung fitness and help lower average blood sugar levels over time, with few negative side effects. Some studies mention that HIIT might cause a temporary rise in blood sugar immediately after exercise, but this usually balances out during the day. Other research highlights improvements in blood pressure and cholesterol levels without major issues.
Moderate intensity exercise is also considered safe. Studies have found that regular moderate exercise can lower blood sugar levels and reduce the risk of heart disease. Monitoring blood sugar during exercise is important to prevent it from dropping too low. If it does, stopping exercise and consuming a small amount of sugar can help.
Both types of exercise have demonstrated positive effects on health with minimal risk, making them good options for improving blood sugar control.12345Why are researchers excited about this trial?
Most treatments for blood sugar control primarily involve medications like insulin or metformin, which work by influencing insulin levels or sensitivity. But this trial is exploring exercise as a treatment, which is unique because it uses physical activity to manage blood sugar. High Intensity Interval Training (HIIT) is particularly exciting because it involves short bursts of intense exercise that can improve sugar metabolism and insulin sensitivity more efficiently than traditional methods. Meanwhile, moderate intensity aerobic training offers a more sustained approach over consecutive days, potentially benefiting those who prefer steady-state exercises. Researchers are eager to discover if these exercise protocols can offer effective, non-pharmaceutical options for managing blood sugar levels.
What evidence suggests that this trial's exercise protocols could be effective for blood sugar control?
This trial will compare the effects of high-intensity interval training (HIIT) and moderate-intensity aerobic exercise on blood sugar control. Research has shown that HIIT, involving short bursts of intense exercise followed by rest, can significantly improve blood sugar control and insulin resistance in people with diabetes. Participants in one arm of this trial will engage in HIIT. Meanwhile, those in another arm will perform moderate-intensity aerobic exercise, which involves maintaining a steady pace and also helps lower blood sugar and improve insulin use. While HIIT might lead to faster improvements, both exercise types benefit blood sugar management and overall health.678910
Who Is on the Research Team?
Jeanne Noble, MD
Principal Investigator
University of California, San Francisco
Are You a Good Fit for This Trial?
This trial is for adults who do not have diabetes or are pre-diabetic. Participants should be able to safely perform exercise and wear a continuous glucose monitor. People with health issues that make exercise unsafe cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants complete two distinct exercise protocols: five consecutive days of Zone 2 aerobic exercise and a single session of high-intensity interval training (HIIT)
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- High Intensity Interval Training
- Moderate Intensity aerobic training
Trial Overview
The study compares two types of exercise: five days of moderate-intensity aerobic workouts versus one session of high-intensity interval training (HIIT), to see which better controls blood sugar in non-diabetic and pre-diabetic adults.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Five consecutive days of moderate intensity aerobic exercise
One session High-Intensity Interval training
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Francisco
Lead Sponsor
Citations
The effects of high-intensity interval training on glucose ...
HIIT intervention led to significant improvement in glycemic control and insulin resistance in subjects with diabetes compared with CON-group.
2.
researchgate.net
researchgate.net/publication/281268584_The_effects_of_high-intensity_interval_training_on_glucose_regulation_and_insulin_resistance_a_meta-analysisThe effects of high‐intensity interval training on glucose ...
HIIT appears effective at improving metabolic health, particularly in those at risk of or with type 2 diabetes. Larger randomized controlled ...
3.
nutritionletter.tufts.edu
nutritionletter.tufts.edu/subscriber-only/high-intensity-interval-training-can-help-control-type-2-diabetes/High-Intensity Interval Training Can Help Control Type 2 ...
The review found that people with type 2 diabetes who participated in high-intensity interval training (known as HIIT) had better blood sugar ...
Efficacy of high‐intensity interval training in... : Diabetes ...
Additionally, HIIT consistently demonstrated significant improvements in CRF across five reviews (WMD: 3.35–6.38 mL/kg/min; SMD: 4.03–5.63; Figure 3A) compared ...
5.
examine.com
examine.com/research-feed/study/WdVX50/?srsltid=AU7gw4VaXIriNq3gmb4RMzOdDjJcOVoaaUnAxflQc9oUmxswZuEhS6w3Afternoon HIIT may be better than morning ...
During week 1, morning HIIT workouts increased average daily blood glucose levels by 6.9 mmol/liter for the exercise days compared to the pre- ...
High intensity interval training exercise-induced physiological ...
HIIT resulted in significant decrease in DBP, SBP, and WC. HDL-C significantly increased in HIIT group. No significant changes in TG and BG levels in HIIT group ...
Metabolic Effects of Isoenergetic High-Intensity Interval ...
RESULTS: Average whole-day glucose levels were higher on the day of HIIT (167.48 ± 66.96 mg/dL; group × time P = 0.021) and MICT (166.46 ± 61.35 mg/dL ...
Effects of high-intensity interval exercise versus continuous ...
The major novel finding in this study was that a single session of HIIT improved postprandial glycemia in overweight or obese adults during the 24 h following ...
How high intensity exercise affects your blood sugar levels
The findings suggest that HIIT is effective in improving metabolic health, particularly for individuals at risk of or with type 2 diabetes.
Intensive lifestyle intervention including high ...
In conclusion, we showed that a 9-month intensive lifestyle intervention including HIIT and MedD improves FPG, fasting insulin, and insulin sensitivity, ...
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