fMRI Neurofeedback for Brain Tumor

This trial explores whether fMRI neurofeedback, a brain imaging technique, can shift language functions away from areas affected by a glioma before surgery. Participants will undergo neuroimaging sessions to determine if the technique can improve language skills by engaging different brain regions. This presurgical strategy aims to make surgery safer and more effective. Individuals diagnosed with a WHO grade II-III glioma in the brain's language areas and planning surgery might be suitable for this study. As an unphased trial, it offers a unique opportunity to contribute to innovative research that could enhance surgical outcomes for future patients.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team to get a clear answer.

Research has shown that fMRI neurofeedback is generally safe and well-tolerated by patients. One study on depression found a similar fMRI neurofeedback system effective without major side effects. Another study involving individuals with movement disorders reported that participants managed the treatment well, experiencing no significant negative effects.

Unlike standard treatments for brain tumors that often focus on surgery, radiation, or chemotherapy, fMRI neurofeedback (NF) offers a unique approach by harnessing real-time brain imaging to enhance brain function before surgery. This technique specifically targets the eloquent language cortex, aiming to improve patients' cognitive outcomes by training their brains in a way that traditional methods do not. Researchers are excited about this trial because it could lead to a non-invasive, personalized way to prepare the brain for surgery, potentially improving recovery and preserving critical language functions.

Research has shown that fMRI neurofeedback can help the brain redirect activity away from areas affected by glioma, a type of brain tumor. Studies have found that this technique can improve brain function and behavior, although more research is needed to fully understand it. In this trial, all participants will receive an fMRI neurofeedback intervention as a presurgical prehabilitation strategy. fMRI neurofeedback has successfully changed how different parts of the brain connect, potentially improving skills like language and focus. Additionally, fMRI techniques have enhanced recovery after brain tumor surgeries, leading to fewer issues with language and movement. These findings suggest that fMRI neurofeedback may be a promising tool for managing the effects of brain tumors.¹³⁵⁶⁷