Nutritional Intervention for Ascites
(SUPPRESS-HE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study will evaluate whether a nutritional intervention is better than another to reduce the incidence of overt hepatic encephalopathy in patients undergoing TIPS insertion for refractory ascites.
Who Is on the Research Team?
Amine Benmassaoud, MD
Principal Investigator
Research Institute of the McGill University Health Centre
Are You a Good Fit for This Trial?
This trial is for adults with liver cirrhosis who are moderately malnourished and scheduled to have a TIPS procedure due to fluid buildup (ascites) that hasn't responded to other treatments.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a personalized nutritional intervention to prevent overt hepatic encephalopathy
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- High Energy and High Protein Diet 1
- High Energy and High Protein Diet 2
Trial Overview
The study compares two types of high-energy, high-protein diets given after the TIPS procedure to see which one better prevents serious brain-related complications called hepatic encephalopathy.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
As participants are blinded, description of the arm is meant to maintain the blinding. Participants will meet the study dietitian who will perform a nutritional assessment. The study dietitian will then prescribe a high-energy and high-protein diet with or without the use of oral nutritional supplements that will fit your taste preferences and dietary needs. The nutritional intervention will focus on having 3 meals per day and 3 snacks per day, including at bedtime.
As participants are blinded, description of the arm is meant to maintain the blinding. Participants will meet the study dietitian who will perform a nutritional assessment. The study dietitian will then prescribe a high-energy and high-protein diet with or without the use of oral nutritional supplements that will fit your taste preferences and dietary needs. The nutritional intervention will focus on having 3 meals per day and 3 snacks per day, including at bedtime.
Find a Clinic Near You
Who Is Running the Clinical Trial?
McGill University Health Centre/Research Institute of the McGill University Health Centre
Lead Sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.