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Transcranial Magnetic Stimulation for Fibromyalgia

(PRANCIR Trial)

ML
DW
Overseen ByDarius Williams
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: Duke University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This pilot feasibility study aims to evaluate transcranial magnetic stimulation (TMS) targeting the prefrontal cortex in patients with fibromyalgia syndrome (FMS). The study will assess preliminary efficacy and mechanisms of central nervous system changes using neuroimaging, behavioral tasks, sensory testing, and neuroimmune markers. Participants will undergo MRI scans, multi-day TMS sessions, and complete questionnaires. The goal is to generate pilot data for future trials on neuromodulation for chronic pain.

Who Is on the Research Team?

KT

Katherine T Martucci, PhD

Principal Investigator

Duke University

Are You a Good Fit for This Trial?

This trial is for women aged 18 and older who have been diagnosed with fibromyalgia by a doctor, can read and understand English, agree to keep their medications and therapy unchanged during the study, and do not use opioid painkillers. People with MRI restrictions (like metal implants or claustrophobia), certain medical issues, or men cannot join.

Inclusion Criteria

I am a woman who is 18 years old or older.
I have been diagnosed with primary fibromyalgia by my doctor.
If enrolled in psychotherapy, verbal agreement to maintain psychotherapy without change or stopping during the study
See 4 more

Exclusion Criteria

History of seizure except therapeutically induced by ECT, history of epilepsy in self or first degree relatives, stroke, brain surgery, head injury, cranial metal implants, known structural brain lesion, devices affected by TMS (pacemaker, medication pump, cochlear implant, implanted brain stimulator)
I am male.
Limited ability to participate fully in behavioral tasks or longitudinal follow-up (e.g., plans to move out-of-state within 3 months)
See 14 more

What Are the Treatments Tested in This Trial?

Interventions

  • Transcranial Magnetic Stimulation (TMS)

Trial Overview

The study is testing transcranial magnetic stimulation (TMS) applied to the prefrontal cortex in women with fibromyalgia. Participants will have several TMS sessions along with MRI scans, sensory tests, behavioral tasks, and questionnaires to see if TMS helps manage chronic pain.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Active TMSExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Duke University

Lead Sponsor

Trials
2,495
Recruited
5,912,000+

American Fibromyalgia Syndrome Association

Collaborator

Trials
2
Recruited
90+

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