Music Therapy for Glioblastoma

(MELODY Trial)

This trial explores whether music therapy can improve the quality of life for individuals with glioblastoma, a type of brain cancer, who are receiving standard treatment. Participants will either engage in live music sessions with a therapist online or listen to a playlist created with a therapist, both aiming to determine if music can make a positive difference. Suitable candidates should have glioblastoma, be able to participate in online music sessions, and complete surveys about their quality of life. As an unphased trial, this study offers a unique opportunity to explore innovative therapy options that could enhance quality of life.

The trial does not specify if you need to stop taking your current medications, but you cannot use other standard or investigational cancer treatments while participating.

Research has shown that music therapy is generally safe for people with cancer. Studies have found no reports of negative side effects, indicating that music therapy doesn't cause harm. In fact, it can help reduce symptoms related to cancer and its treatment, such as anxiety.

Researchers are excited about music therapy for glioblastoma because it offers a unique, non-invasive approach that focuses on enhancing patients' quality of life. Unlike traditional treatments like surgery, radiation, and chemotherapy that directly target cancer cells, music therapy aims to reduce stress and improve emotional well-being. In this trial, participants either engage in live virtual sessions with a music therapist or listen to a personalized playlist independently, making it accessible and customizable. This innovative approach could complement existing treatments by providing emotional support without the side effects typically associated with conventional therapies.

Research has shown that music therapy can enhance the quality of life for cancer patients by reducing symptoms like anxiety and stress. In studies involving patients with glioblastoma, a type of brain cancer, music therapy has demonstrated promise. It can make treatments feel less overwhelming and improve mood. This trial will compare two approaches: Arm A participants will receive live music therapy sessions with a Music Therapist, while Arm B participants will listen to a curated playlist independently. Some research also suggests that music might enhance the effectiveness of other treatments by increasing the amount of medicine that reaches the brain. This indicates that music therapy is a valuable support for glioblastoma patients.¹²³⁶⁷