Potassium-Containing Salt Substitute for Kidney Failure

This trial explores the effects of a potassium-containing salt substitute on individuals with end-stage kidney disease undergoing hemodialysis. The researchers aim to determine if this substitute can safely alter blood potassium levels compared to regular table salt. Participants will use the salt substitute for 16 days and regular salt for another 16 days, with a break in between. This trial suits individuals who regularly attend outpatient hemodialysis sessions and do not currently have high potassium levels. As an unphased trial, it offers participants the chance to contribute to important research that could enhance dietary options for those on hemodialysis.

The trial does not specify if you need to stop taking your current medications, but you cannot use other potassium supplements while participating.

Research has shown that salt substitutes with potassium can be risky, especially for people with kidney problems. One study found that these substitutes might lead to hyperkalemia, which means having too much potassium in the blood. This condition can be serious and even life-threatening for some individuals. Another source suggests that the potassium amount in these substitutes is usually small and might not pose a danger to everyone, including those with kidney disease. However, the risk can vary based on individual health conditions. Regularly checking potassium levels when using these substitutes is important, as routine tests can help ensure safety.¹²³⁴⁵

Researchers are excited about these treatments because they explore a potentially safer alternative to traditional salt for people with kidney failure. Most treatments focus on managing symptoms and complications through medication and dietary restrictions. This trial investigates a potassium-containing salt substitute that could help reduce sodium intake without compromising flavor, which is crucial for managing blood pressure and fluid balance in kidney patients. By potentially offering a safer seasoning option, this treatment could enhance dietary management for kidney failure patients, potentially leading to better health outcomes.

Research has shown that salt substitutes with potassium can lower blood pressure by replacing some sodium in regular salt with potassium. However, individuals with chronic kidney disease (CKD) should exercise caution, as these substitutes might cause hyperkalaemia, a condition where too much potassium accumulates in the blood, posing risks for those with kidney issues. This trial will compare the effects of a Potassium-Containing Salt Substitute with Standard Table Salt in participants with kidney failure. Participants will receive both treatments in separate periods to evaluate their impact. For most people without CKD, the benefits of these substitutes may outweigh the risks. Consulting a healthcare provider before using them is important, especially for those with kidney problems.¹²³⁴⁶