Esophageal String Test for Eosinophilic Esophagitis

This trial aims to determine if a simpler test, the esophageal string test (EST), can diagnose eosinophilic esophagitis (EoE), an inflammatory condition that makes swallowing difficult. The EST involves swallowing a pill attached to a string that collects fluid from the esophagus for testing. The trial seeks participants of African descent who have difficulty swallowing. Participants will undergo both the EST and a traditional endoscopy to compare results. As an unphased trial, this study offers a unique opportunity to contribute to research that may simplify EoE diagnosis for future patients.

The trial requires that you stop taking certain medications before participating. You must not have used steroids in the last 4 weeks or certain biologic medications in the last 6 months. If you are currently using anticoagulant medications, you cannot participate.

Studies have shown that the Esophageal String Test (EST) is a safe and easy method for diagnosing eosinophilic esophagitis (EoE). Research indicates that the EST can accurately differentiate between active and inactive EoE in both children and adults. This test is minimally invasive, making it simpler and less risky than other procedures. Participants in earlier studies did not report any major side effects, suggesting the test is generally safe. The EST involves swallowing a capsule attached to a string that collects fluid from the esophagus, which is then checked for signs of inflammation. Previous research has used this method without serious side effects, making it a promising tool for diagnosing EoE.¹²³⁴⁵

The Esophageal String Test is unique because it offers a minimally invasive way to collect esophageal secretions, making it easier and more comfortable for patients compared to traditional endoscopy and biopsy methods. Researchers are excited about this technique because it provides a simpler, less intrusive way to monitor Eosinophilic Esophagitis, potentially leading to more frequent and accurate assessments of the condition. This method could improve patient experience and compliance, while still delivering valuable diagnostic information.

Research shows that the esophageal string test (EST), which participants in this trial will undergo, effectively diagnoses eosinophilic esophagitis (EoE). One study found that the EST had good accuracy, with a performance score of 0.83 out of 1. It correctly identified EoE in 80% of cases and accurately ruled it out in 75% of cases. This indicates the test's reliability in many instances. Additionally, many patients and parents preferred the EST over traditional endoscopy because it is simpler and less invasive. Overall, the EST appears to be a promising tool for monitoring and diagnosing EoE.¹²⁶⁷⁸