Focused Ultrasound for Epilepsy
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is to investigate the effects of a non-invasive, low intensity focused ultrasound (LIFU) stimulation on seizure frequency and the epileptogenic network in drug-resistant epilepsy. LIFU uses focused sound waves to modulate deep brain regions and to enable changes in brain network activity. Encephalography (EEG) and behavioral tasks will also be used to study how LIFU affects brain activity.
Who Is on the Research Team?
Joline M Fan, MD, MS
Principal Investigator
University of California, San Francisco
Are You a Good Fit for This Trial?
This trial is for people with epilepsy who continue to have seizures despite taking medication. Participants should have drug-resistant focal epilepsy and be able to undergo non-invasive brain stimulation procedures.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
The study tests a new, non-invasive treatment called low intensity focused ultrasound (LIFU), which uses sound waves aimed at specific brain areas to try to reduce seizure frequency in people with drug-resistant epilepsy.
How Is the Trial Designed?
2
Treatment groups
Active Control
Participants in this single experimental group will undergo a series of LIFU sessions to determine optimal clinical response. Each participant will receive active LIFU stimulation of up to three personalized brain targets. The study utilizes a within-subject, sham-controlled design where participants receive both active LIFU and sham (placebo) stimulation across different sessions to compare physiological and clinical responses.
If an optimal target is identified, patients will undergo serial stimulation of the optimal target.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Francisco
Lead Sponsor
Attune Neurosciences Inc
Industry Sponsor
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