Whole Body Vibration for Spinal Degeneration
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand how whole body vibration (WBV), similar to what military personnel experience, affects the spine over time. It will explore the impact of past and current WBV on spinal health and pain, with a focus on how hydration levels, including water intake, alter spine response. The study involves different groups: some examine long-term effects, others immediate changes, and some assess hydration's role in spine health. Veterans who have experienced WBV in military or civilian jobs, can sit upright for an hour, and are ambulatory might be suitable participants. As an unphased study, this trial offers a unique opportunity to contribute to valuable research that could enhance understanding and care of spinal health.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that whole body vibration is safe for spinal health?
Research shows that whole body vibration (WBV) can negatively affect the spine, especially with long-term exposure. Studies have found that people exposed to WBV for several years may face a higher risk of spinal issues, such as low back pain and early wear and tear of spinal discs. Constant shaking can stress the spine over time.
In this trial, researchers are carefully monitoring the safety of WBV. Advanced MRI scans are being used to observe how the spine reacts to WBV, both in the short term and over longer periods. One focus is hydration, which refers to water intake. The trial examines whether staying hydrated can help maintain spinal health when exposed to WBV.
While WBV is known to cause some spine issues, this trial aims to find safer ways to manage or reduce those effects. It is important to note that the trial does not test a new medication or treatment but seeks to understand how WBV affects the spine.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores how whole body vibration (WBV) affects spinal health in ways that current treatments don't. Unlike traditional therapies that mainly focus on managing pain or improving mobility, this study investigates the potential for WBV to influence the spine's structure and fluid dynamics directly. One unique aspect of this trial is its exploration of how hydration levels impact the spine's response to vibration, which could lead to new strategies for preventing or treating spinal degeneration. This approach could open up new pathways for rehabilitation and prevention that are more individualized and potentially more effective over time.
What evidence suggests that this trial's treatments could be effective for spinal degeneration?
Research has shown that whole-body vibration (WBV) can affect the spine, particularly the soft discs between the spine's bones. Some studies suggest that over time, WBV might cause these discs to wear down, leading to back pain. However, other research indicates that WBV therapy can sometimes help reduce pain and improve movement in people with low back pain. This trial includes separate arms to explore different aspects of WBV's effects. One arm investigates the longitudinal effects of current or prior WBV on lumbar spine health. Another arm examines how WBV acutely affects lumbar disc fluid flow. Additionally, the study explores how staying hydrated might influence the spine's response to WBV. By keeping the spine's cushioning well-hydrated, it might better handle vibration, potentially benefiting people whose jobs expose them to WBV.12678
Who Is on the Research Team?
Brian D Stemper, PhD
Principal Investigator
Milwaukee VA Medical Center
Are You a Good Fit for This Trial?
This trial is for U.S. military veterans aged 20-45 who can speak English, have a BMI under 30, can sit upright for an hour, drive to Deerfield, IL, and are able to walk on their own.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Initial MRI scans and questionnaires to assess baseline spine health and whole body vibration exposure history
Acute WBV Exposure
Participants undergo experimental whole body vibration exposure and pre/post MRI scans to assess acute changes
Longitudinal Monitoring
Annual MRI scans and questionnaires to track progression of spine changes over three years
Follow-up
Participants are monitored for safety and effectiveness after the main study phases
What Are the Treatments Tested in This Trial?
Interventions
- Water
Trial Overview
The study uses advanced MRI techniques to examine the spine's structure and physiology after exposure to whole body vibration (WBV), both from past military service and current civilian jobs like truck driving.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Active Control
This arm will determine whether individual hydration state influences IVD water dynamics following acute vibrational exposure. The objective is to assess the impact of hydration on IVD fluid distribution and transport in response to acute vibration utilizing multi-parametric MRI analysis. This will allow for evaluation of hydration as a potential factor for rehabilitation, treatment, and prevention of early degeneration related to WBV. MRI scans will be obtained under two conditions: hydrated and dehydrated. For the hydrated MRI scans, research subjects will be asked to consume a minimum of 2.7 liters of fluid per day for three days leading up the MRI date. For the dehydrated MRI scans, research subjects will be asked to consume about 1.3 liters of fluid per day for three days leading up to the MRI date. WBV induced changes to IVD water dynamics will be compared within subjects for the hydration, dehydration and control conditions.
Determine the impact of acute and longitudinal WBV on lumbar spine endplate health. The objective is to perform a repeated measures study using multi-parametric MRI to assess Veteran endplate health. Veterans will participate in pain assessments and MRI scans annually for three years to track the progression of whole body vibration-related changes in the lumbar spine endplates and intervertebral discs. Current and prior whole body vibration characteristics will be correlated to pain scores and MRI changes.
The objective is to perform a repeated measures study to quantify changes in lumbar spine T2 relaxation times and volumetric MRI data following acute experimental vibrational exposure to determine fluid transport patterns and morphological changes. Veterans will participate in pain questionnaires, and receive Upright MRI scans prior to and immediately following 30 minutes of low magnitude whole body vibration. This unique protocol will allow us to assess acute changes in MR metrics and structural dimensions of the lumbar spine following exposure to WBV by comparing measurements obtained immediately following experimental WBV to pre-WBV measurements.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Milwaukee VA Medical Center
Lead Sponsor
Medical College of Wisconsin
Collaborator
Indiana University
Collaborator
VA Office of Research and Development
Collaborator
Naval Aeromedical Research Unit, Dayton
Collaborator
Citations
Occupational Exposure to Whole Body Vibration Among ...
This study will investigate acute and chronic effects of occupational whole-body vibration on the health of lumbar spine endplates and ...
Whole Body Vibration for Spinal Degeneration
This N/A medical study run by Milwaukee VA Medical Center needs participants to evaluate whether Water will have tolerable side effects ...
Whole-Body Vibration to Treat Low Back Pain: Fact or Fad?
The purpose of this systematic review was to evaluate the current evidence base for whole-body vibration as a treatment for low back pain (LBP).
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frontiersin.org
frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2023.1069568/fullLong-term whole-body vibration induces degeneration of ...
Conclusion: The present study revealed significant damage effects of Whole body vibration on intervertebral disc and facet joint in a bipedal ...
Vibration therapy to improve pain and function in patients with ...
The results showed that both whole-body vibration therapy and local vibration therapy improved patients' low back pain. In terms of improvement ...
Deleterious effects of whole‐body vibration on the spine - PMC
Such studies have found that greater duration of exposure (over 5 years) to WBV is associated with increased risk for spinal pathologies and that the lumbar ...
Whole Body Vibration - an overview
With the knowledge that whole-body vibration is a real medical problem, when we look at the possible effects: low back pain, early degeneration of the spinal ...
Long-term whole-body vibration induces degeneration ... - PMC
The present study revealed significant damage effects of Whole body vibration on intervertebral disc and facet joint in a bipedal mouse model.
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