40 Participants Needed

Mindful Self-Compassion for Anxiety and Depression

Recruiting at 1 trial location
AS
CS
Overseen ByCharisma, Study Coordinator
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests an 8-week Mindful Self-Compassion training to determine its effectiveness in reducing symptoms of anxiety and depression. Participants will attend weekly group classes, and their progress will be compared to a group receiving standard care without the new training. This trial is ideal for individuals diagnosed with anxiety disorders or major depressive disorder who feel they lack self-compassion.

As an unphased trial, this study provides a unique opportunity to explore a new approach to managing anxiety and depression through self-compassion.

Will I have to stop taking my current medications?

The trial allows some psychiatric medications, like certain sleep medications and anti-depressants, if you've been on a stable dose for at least 8 weeks before starting and plan to continue at the same dose during the trial. However, medications like barbiturates or antipsychotics are not allowed.

What prior data suggests that Mindful Self-Compassion is safe for treating anxiety and depression?

Research has shown that mindfulness practices, such as Mindful Self-Compassion, are generally safe and manageable for most people. Studies have found that these practices can reduce emotional distress without major side effects. However, some individuals might initially experience increased anxiety or depression. These feelings are uncommon and typically subside with continued practice. Overall, Mindful Self-Compassion is considered a safe option for managing anxiety or depression.12345

Why are researchers excited about this trial?

Mindful Self-Compassion (MSC) is unique because it offers a holistic, non-pharmaceutical approach to managing anxiety and depression. Unlike standard treatments, such as antidepressants and cognitive-behavioral therapy, MSC provides a structured program that focuses on building self-kindness and mindfulness skills in a supportive group setting. Researchers are excited about MSC because it empowers individuals to cultivate emotional resilience and self-compassion, potentially reducing symptoms without the side effects often associated with medications. This innovative approach could provide a valuable alternative or complement to traditional therapies, appealing to those seeking mental health solutions beyond conventional drugs.

What evidence suggests that Mindful Self-Compassion is effective for anxiety and depression?

Research has shown that Mindful Self-Compassion (MSC), which participants in this trial may receive, can help reduce anxiety and depression. One study found that learning self-compassion improved mindfulness and self-kindness while lowering stress, self-criticism, anxiety, and depression. Another study demonstrated that mindfulness-based methods, like MSC, effectively reduce anxiety compared to other treatments. These findings suggest that practicing MSC might be a helpful way to manage anxiety and depression.23678

Who Is on the Research Team?

EH

Elizabeth Hoge, MD

Principal Investigator

Georgetown University

Are You a Good Fit for This Trial?

This trial is for adults with anxiety disorders (like social anxiety, generalized anxiety, panic disorder, or agoraphobia) or major depression who feel they aren't very self-compassionate. Participants must understand the study and agree to all parts of it. People can't join if they've had certain mental health treatments recently, have severe medical conditions that could interfere, are pregnant, prisoners, or plan to be away during the study.

Inclusion Criteria

I can understand and agree to the study's procedures.
Must score low on self-compassion, as measured by the self-compassion scale
Must understand study procedure and willing to participate in all testing visits, and treatment as assigned
See 1 more

Exclusion Criteria

Pregnant women
I have had serious thoughts or actions of suicide in the last year.
Prisoners
See 10 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive Mindful Self-Compassion training in weekly classes for 8 weeks

8 weeks
8 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Mindful Self-Compassion
Trial Overview The trial tests an 8-week Mindful Self-Compassion program against a control group not receiving this training. It aims to see if this approach helps reduce symptoms of anxiety and depression in participants compared to those who don’t receive the intervention.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Mindful Self-CompassionExperimental Treatment1 Intervention
Group II: Treatment as Usual (TAU)Active Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Georgetown University

Lead Sponsor

Trials
355
Recruited
142,000+

Published Research Related to This Trial

Self-compassion, which includes self-kindness, common humanity, and mindfulness, is linked to better mental health and less psychological distress, highlighting its importance in emotional well-being.
The Mindful Self-Compassion (MSC) program, an 8-week course with weekly sessions, effectively teaches participants to develop self-compassion through various meditative and practical exercises, demonstrating its potential as a therapeutic intervention.
Self-compassion in clinical practice.Germer, CK., Neff, KD.[2013]
Mindfulness-Based Compassionate Living (MBCL) was found to be feasible and acceptable for adults with recurrent depression, with no dropouts and high attendance rates (average 7.52 out of 8 sessions) during the intervention.
Preliminary results indicated that while the second group showed a reduction in depressive symptoms and an increase in self-compassion, the first group did not experience significant changes, highlighting the need for further research in a larger, randomized controlled trial.
The Co-creation and Feasibility of a Compassion Training as a Follow-up to Mindfulness-Based Cognitive Therapy in Patients with Recurrent Depression.Schuling, R., Huijbers, M., Jansen, H., et al.[2020]
The online compassion-focused intervention, mindfulness-based compassionate living (MBCL), significantly reduced depressive and anxiety symptoms and increased self-compassion in 122 participants over 8 weeks, with medium to large effect sizes.
These positive effects were maintained for 6 months after the intervention, indicating that MBCL can be an effective long-term strategy for individuals with high self-criticism.
An Internet-Based Compassion-Focused Intervention for Increased Self-Criticism: A Randomized Controlled Trial.Krieger, T., Reber, F., von Glutz, B., et al.[2019]

Citations

Long-term effectiveness of the Mindful Self-Compassion ...(2019) found that self-compassion training improved levels of mindfulness and self-compassion skills and reduced stress, self-criticism, anxiety and depressive ...
Mindfulness-Based Interventions for Anxiety and DepressionStudies comparing MBSR to active control conditions have demonstrated that MBIs are superior in reducing anxiety symptoms. Hoge and colleagues found that MBSR ...
A Pilot StudyThis study examines the effectiveness of online Mindful Self-Compassion (MSC) training, which cultivates warmth and safety, and has been shown to increase self ...
Effects of Mindfulness on Psychological Health: A Review of ...We conclude that mindfulness brings about various positive psychological effects, including increased subjective well-being, reduced psychological symptoms and ...
Self-compassion mediates the influence of mindfulness on ...Evidence supports mindfulness-based interventions in reducing stress, depression, and anxiety, while enhancing quality of life. A better ...
Meditation and Mindfulness: Effectiveness and Safety | NCCIHThe most commonly reported negative effects were anxiety and depression. In an analysis limited to 3 studies (521 participants) of mindfulness- ...
The effect of mindfulness meditation on depressive ...The findings suggest a positive effect of mindfulness meditation on depressive symptoms in individuals with depression during the COVID-19 pandemic.
The effect of self-compassion versus mindfulness ...Some studies suggest that self-compassion is a stronger predictor of well-being than mindfulness, although findings related to anxiety are mixed ...
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