Yogurt Consumption for Diet

(YOGBIO Trial)

JD
VG
Overseen ByValérie Guay, MSc
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Laval University

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how yogurt consumption might reduce the risk of developing type 2 diabetes. Researchers will test different yogurt amounts in the diet to identify biological markers that indicate yogurt intake. Participants will follow diets with varying yogurt amounts, including a no-yogurt option, to observe the effects on their bodies. This study suits generally healthy adults who can eat plain yogurt daily for three weeks and avoid adding milk or sugar to coffee or tea. As an unphased trial, it offers a unique opportunity to contribute to understanding the potential health benefits of yogurt.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. However, it does mention that participants should not have severe chronic illnesses or be undergoing treatment for certain conditions, which might imply some restrictions.

What prior data suggests that this method is safe for identifying biomarkers of yogurt intake?

Studies have shown that yogurt is generally safe and well-tolerated by most people. Research indicates that eating yogurt links to several health benefits, such as better nutrition and improved metabolism. These studies did not find any major negative effects from eating yogurt.

Additionally, yogurt is a common food that many people already eat without major safety concerns. It often associates with positive health outcomes, like a lower risk of type 2 diabetes and better weight management. This suggests that for most people, eating yogurt in the amounts studied is safe.

Overall, the evidence supports that yogurt is safe to eat. However, consulting a healthcare professional is always advisable if specific dietary restrictions or allergies exist.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it aims to identify specific biomarkers that can objectively indicate yogurt consumption. Unlike other dietary studies that rely on self-reported data, this trial uses cutting-edge metabolomics to potentially provide more accurate and reliable data. By understanding these unique biomarkers, scientists hope to better understand the health impacts of yogurt consumption, paving the way for personalized dietary recommendations.

What evidence suggests that this trial's treatments could be effective for identifying biomarkers of yogurt consumption?

Research has shown that eating yogurt links to a healthier diet and better metabolic health. People who consume yogurt often have lower body weight and are less likely to be overweight or obese. Yogurt might also help reduce inflammation, which connects to obesity and other health problems. Some studies suggest that eating yogurt could be more effective at reducing waist size than drinking milk. This trial will compare different levels of yogurt consumption, including a yogurt-free diet, to assess its impact on health. Overall, these findings suggest that yogurt may aid in weight management and improve health.678910

Who Is on the Research Team?

JD

Jean-Philippe Drouin-Chartier, PhD

Principal Investigator

Laval University

Are You a Good Fit for This Trial?

This trial is for adults aged 18-70 with a BMI between 18 and 40 who are generally healthy, willing to eat plain yogurt daily, and can avoid milk/cream/sugar in coffee or tea. People with lactose intolerance, certain chronic illnesses, recent blood donation, drug/alcohol abuse, unstable weight, or allergies to diet components cannot join.

Inclusion Criteria

Willingness to consume plain yogurt daily for 3 weeks
I am willing to drink coffee or tea without milk, cream, or sugar for 4 weeks.
I am between 18 and 70 years old.
See 1 more

Exclusion Criteria

Allergies or aversions to components of the diets
Lactose intolerance
Blood donation within 2 months
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Diet Intervention

Participants undergo four 7-day diet periods with different yogurt servings, each separated by a 1-week washout period.

7 weeks
3 visits per week (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the diet interventions.

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Identification of Objective Metabolomics-based Biomarkers of Yogurt Consumption

Trial Overview

The study tests how different amounts of yogurt (none, low, moderate, high) affect the body by measuring thousands of metabolites in blood samples. Each participant tries all four diets over separate weeks to help identify reliable markers that show if someone has eaten yogurt.

How Is the Trial Designed?

4

Treatment groups

Experimental Treatment

Placebo Group

Group I: 90 g per 2,380 kcal per day of yogurt (0.5 reference serving of yogurt per 2,380 kcal per day)Experimental Treatment1 Intervention
Group II: 350 g per 2,380 kcal per day of yogurt (2 reference servings per 2,380 kcal per day).Experimental Treatment1 Intervention
Group III: 175 g per 2,380 kcal per day of yogurt (1 reference serving of yogurt per 2,380 kcal per day)Experimental Treatment1 Intervention
Group IV: 125 g per 2,380 kcal per day of a soy-based pudding (i.e., yogurt-free diet);Placebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Laval University

Lead Sponsor

Trials
439
Recruited
178,000+

Citations

Yogurt consumption is associated with higher nutrient intake ...

Yogurt consumption has been associated with higher nutrient intakes, better diet quality and improved metabolic profiles in adults.

Evaluating the Effects of Full-Fat Yogurt Consumption on ...

Compared with non-fat yogurt intake, circulating immature granulocyte concentrations were lower following full-fat yogurt intake, but there were no other ...

Low-fat yogurt consumption maintains biomarkers of ...

Yogurt consumption may help reduce chronic inflammation associated with obesity. However, the underlying mechanism(s) by which yogurt consumption modulates ...

Yogurt consumption and risk of accelerated aging

These findings suggest that yogurt consumption may reduce the risk of accelerated aging and may also be linked to a lower risk of overweight status.

Association of Yogurt Consumption with Nutrient Intakes ...

Consumption of yogurt was also associated with lower body weight, body mass index (BMI), and 23% showed a lower risk of being overweight/obese among adults only ...

Postprandial Responses on Serum Metabolome to Milk ... - PMC

Here, we aimed at identifying BFI of both milk (M) and yogurt (Y) in 14 healthy young (20–35 years) and 14 older (65–80 years).

Identification of Objective Metabolomics-based Biomarkers of ...

The project aims to discover and validate biomarkers of yogurt intake. We will conduct a randomized, crossover, dose-response feeding trial ...

Two untargeted metabolomics reveals yogurt-associated ...

Yogurt is an important dietary sources of probiotic [2]. A systematic review included 10 cohort studies reported the inverse association between ...

Yogurt consumption associated with reduced risk of T2D

In a meta-analysis of prospective cohort studies, yogurt intake was associated with a 20% reduction in risk of MetS development. How might ...

Yogurt consumption and risk of mortality from all causes, CVD ...

High intake of yogurt compared with low intake was significantly associated with a lower risk of deaths from all causes (pooled RR 0·93; 95 % CI: 0·89, 0·98, I2 ...