Saskatoon Berries for Type 2 Diabetes

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether eating freeze-dried Saskatoon berries can help manage type 2 diabetes (T2D) and prediabetes by improving blood sugar levels and gut health. Participants will consume either Saskatoon berries or a similar amount of freeze-dried apple slices for comparison. The trial seeks individuals who have not started medication for their prediabetes or type 2 diabetes, even if they also have fatty liver disease. The goal is to determine if this natural approach offers a safer option for managing these conditions. As an unphased trial, it provides a unique opportunity to explore a natural, non-medication-based approach to managing diabetes and prediabetes.

Do I have to stop taking my current medications for the trial?

Yes, you must stop taking medications for diabetes, cholesterol, blood pressure, or antibiotics at least one month before joining the trial.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that Saskatoon berries might safely help manage Type 2 Diabetes. In earlier studies, Saskatoon berry powder lowered blood sugar and bad cholesterol levels in mice and rats. A small study with healthy participants found that consuming Saskatoon berries for ten weeks reduced fasting blood sugar and cholesterol without serious side effects. Participants also experienced lower blood pressure and improved gut health.

Other research suggests that people with Type 2 Diabetes tolerate Saskatoon berries well. They are considered a natural food option that could help control blood sugar levels. Overall, these findings suggest Saskatoon berries are likely safe for use.1234

Why are researchers excited about this trial?

Researchers are excited about using freeze-dried whole Saskatoon berries for managing type 2 diabetes because these berries are packed with natural compounds, like anthocyanins, that might help regulate blood sugar levels. Unlike standard diabetes treatments, such as metformin or insulin, which focus on controlling insulin levels or improving insulin sensitivity, Saskatoon berries offer a dietary approach that could provide antioxidant benefits alongside blood sugar control. This natural, food-based treatment is particularly intriguing as it could offer a more holistic way to support diabetes management with fewer side effects than traditional medications.

What evidence suggests that Saskatoon berry might be an effective treatment for type 2 diabetes?

Research shows that Saskatoon berries might help manage type 2 diabetes. In animal studies, Saskatoon berry powder lowered blood sugar, cholesterol, and inflammation, and improved liver health. One study with healthy individuals found that eating Saskatoon berries reduced blood sugar and cholesterol levels and improved blood pressure, with benefits linked to better gut health. This trial will test the effects of freeze-dried whole Saskatoon berries on individuals with type 2 diabetes. Although researchers have not yet tested them in people with diabetes, these findings suggest that Saskatoon berries could be a useful natural option for managing the condition.15678

Are You a Good Fit for This Trial?

This trial is for adults aged 18-74 with untreated pre-diabetes or type 2 diabetes, which may include those with fatty liver disease. Participants must not have started any treatment and should be willing to give informed consent.

Inclusion Criteria

I am between 18 and 74 years old.
I have signed the informed consent form.
I have type 2 diabetes that has not been treated, with or without fatty liver disease.
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks
1 visit (in-person)

Baseline Assessment

Consent and enrollment, dietary intake and physical activity questionnaire, body weight, height, and blood pressure measurements

<1 week
1 visit (in-person)

Treatment

Participants receive 40 g/day of freeze-dried Saskatoon berry or control dried apple slice for 12 weeks

12 weeks
3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, including biochemical analyses and gut microbiome assessment

4 weeks
1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Freeze dried whole Saskatoon berry

Trial Overview

The study tests the effects of consuming freeze-dried whole Saskatoon berries versus apples on blood sugar control, insulin resistance, and gut bacteria in people with pre-diabetes or newly diagnosed type 2 diabetes.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: Freeze dried whole Saskatoon berryExperimental Treatment1 Intervention
Group II: Freeze dried apple slize bulkPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Manitoba

Lead Sponsor

Trials
628
Recruited
209,000+

Citations

Saskatoon Berry Amelanchier alnifolia Regulates Glucose ...

Saskatoon berry intervention normalised body weight and adiposity, improved glucose tolerance, decreased systolic blood pressure, improved heart ...

Effects of Dried Whole Fruits on Metabolism in Diabetes

The effect of Saskatoon berry and its products on metabolic disorders have not been studied in diabetic subjects.

Saskatoon Berry on Metabolism and Gut Microbiota in ...

Freeze dried Saskatoon berry (30 g) will be orally administrated daily for 10 weeks. ... Prediabetic patients (fasting glucose 5.6-6.9 mM/L, HbA1c 5.7-6.9%, or ...

Saskatoon Berry for Metabolism Enhancement

Research has shown that Saskatoon berries can improve metabolism by managing blood sugar levels, reducing inflammation, and supporting heart and liver health.

The Potential Anti-Diabetic Effects of Saskatoon Berry in ...

Dried whole ... This short-term study demonstrates very interesting evidence on potential effectiveness of SBP against type-2 diabetes in db/db mice.

Saskatoon Berries for Type 2 Diabetes · Info for Participants

... Freeze dried whole Saskatoon berry will have tolerable side effects & efficacy for patients with Type 2 Diabetes, Incretin Hormones in ...

Bioactive Components and Health Benefits of Saskatoon Berry

However, Saskatoon berries, as natural food, may be one of the best alternatives for the prevention and treatment of diabetes in the future.

Dose-Responses Relationship in Glucose Lowering and ...

Administration of freeze-dried powder of Saskatoon berry (SB), a popular fruit enriched with antioxidants, reduced glucose level, inflammatory markers and ...