Messaging Strategies for Cardiovascular Disease
(ADHERE-ASCVD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores the best ways to encourage individuals with heart disease or diabetes to refill and adhere to their statin medications, which lower cholesterol. Researchers aim to determine if different communication methods, such as text messages, emails, or patient portal messages, can increase prescription refill rates compared to no additional messages. Participants may initially receive a text message reminder and, if they do not refill their prescription, a follow-up through another method like email. The trial is ideal for those with heart disease or diabetes who have not refilled their statin prescriptions in the past three months and have an active patient portal account. As an unphased trial, this study offers a unique opportunity to contribute to research that could enhance medication adherence strategies for many patients.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. It focuses on improving statin refill and adherence, so it's likely you will continue your current medications unless advised otherwise by your doctor.
What prior data suggests that these messaging strategies are safe for improving statin adherence?
Past studies have shown that sending text messages (SMS) helps people remember to take medications for conditions like high cholesterol. For instance, reminder texts improved adherence to cholesterol-lowering drugs, resulting in better health outcomes. Only a few individuals reported issues with receiving these messages, while many found them useful.
Research suggests that secure portal messaging through online health portals aids in following medication schedules. This technology often reduces medication errors and enhances safety by facilitating clear communication between patients and healthcare providers.
The research on non-secure email is less definitive. Some studies have examined email reminders for medication adherence, but results are not consistently strong. The effectiveness of emails as reminders can depend on their content and delivery.
Overall, these messaging methods are safe and primarily serve to send reminders and information. Issues like missing a message or preferring a different communication method may arise, but these are usually minor concerns.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores innovative ways to improve adherence to dyslipidemia therapy, a crucial aspect of cardiovascular disease management. Unlike traditional methods that rely solely on patients remembering to refill their prescriptions, this trial tests the effectiveness of different messaging strategies, such as SMS, secure portal messages, and emails, to encourage timely statin refills. By examining which combination of reminders works best, the study aims to find out how to enhance patient compliance, potentially leading to better health outcomes. This approach could offer a simple yet impactful way to improve cardiovascular care by ensuring patients stick to their prescribed treatments.
What evidence suggests that this trial's messaging strategies could be effective for improving statin refill and adherence in patients with ASCVD or diabetes?
This trial will evaluate different messaging strategies to improve adherence to dyslipidemia therapy. Research has shown that text messages can help people remember to take their medication. In one study, text reminders increased the number of people taking their medication from 0% to 90%. Participants in this trial may receive SMS reminders as part of their treatment arm.
For secure online messages, studies have found that patients using online portals to refill prescriptions tend to take their medication more regularly. This method greatly improved prescription refill rates and effectively managed cholesterol levels. Some participants in this trial will receive secure portal messages as part of their treatment arm.
Regular email reminders also help, but the improvement is smaller. One study found a 4% increase in medication availability when patients received email reminders. Participants in this trial may receive non-secure email reminders as part of their treatment arm. Overall, different types of messaging can help people stick to their medication schedules, and this trial will explore these strategies.13678Are You a Good Fit for This Trial?
This trial is for adults (18+) with heart disease or diabetes who are Kaiser Permanente Northern California members, have not filled a statin prescription in the last 3 months, have less than 80% statin adherence over the past year, and have an active kp.org account plus valid email and text-capable phone.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Initial Outreach
Participants receive an initial outreach message encouraging statin refill, with a 14-day window to refill
Follow-up Outreach
Non-responders receive a second outreach message using the same or different communication method
Follow-up
Participants are monitored for statin refill and adherence outcomes over a longer term
What Are the Treatments Tested in This Trial?
Interventions
- Adherence to Dyslipidemia Therapy
Trial Overview
The study tests whether different ways of sending reminders—like text messages, secure portal messages, or emails—help people refill their statin prescriptions more than usual care. Some may get follow-up messages if they don't respond at first.
How Is the Trial Designed?
13
Treatment groups
Experimental Treatment
Active Control
Participants in this arm will receive an initial secure portal message encouraging statin refill. Participants who do not refill their prescription within 14 days will receive no additional outreach (usual care).
Participants in this arm will receive an initial secure portal message encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a second secure portal message.
Participants in this arm will receive an initial secure portal message encouraging statin refill. Participants who do not refill their prescription within 14 days will receive an SMS (text message).
Participants in this arm will receive an initial secure portal message encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a non-secure email.
Participants in this arm will receive an initial SMS (text message) encouraging statin refill. Participants who do not refill their prescription within 14 days will receive no additional outreach (usual care).
Participants in this arm will receive an initial SMS (text message) encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a secure portal message.
Participants in this arm will receive an initial SMS (text message) encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a second SMS.
Participants in this arm will receive an initial SMS (text message) encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a non-secure email.
Participants in this arm will receive an initial non-secure email encouraging statin refill. Participants who do not refill their prescription within 14 days will receive no additional outreach (usual care).
Participants in this arm will receive an initial non-secure email encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a secure portal message.
Participants in this arm will receive an initial non-secure email encouraging statin refill. Participants who do not refill their prescription within 14 days will receive an SMS (text message).
Participants in this arm will receive an initial non-secure email encouraging statin refill. Participants who do not refill their prescription within 14 days will receive a second non-secure email.
Participants in this arm will receive usual care with no proactive outreach during the study period.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Kaiser Permanente
Lead Sponsor
Citations
Addressing adherence challenges in long-term statin ... - PMC
The study findings revealed a 4 % increase in medication possession ratios (MPRs) for dyslipidemia patients and a 5 % increase for diabetes ...
Adherence to Lipid‐Lowering Therapies and ...
To our knowledge, this is the first systematic review to evaluate the impact of adherence to statin or nonstatin LLTs on cardiovascular outcomes ...
Nonadherence to lipid‐lowering therapy and strategies ... - PMC
Adherence is critical for LLT effectiveness, with cumulative evidence linking poor LLT adherence and statin intolerance with worse outcomes and increased ...
Interventions to improve adherence to lipid-lowering drugs
Our findings show that while interventions were generally effective in improving medication adherence, both as continuous (SMD 0.17, 95% CI [ ...
Adherence to Statin Therapy and Attainment of LDL ...
Results: Overall, 80% of the patients had a statin prescription and of those, 89% were adherent. The proportion of patients who reached LDLc ...
Study Details | NCT07522645 | Adherence to Dyslipidemia ...
Participants will receive an initial non-secure email encouraging statin refill. Emails may include informational content and reminders but are delivered ...
Telehealth and challenges of statin adherence in patients with ...
The main hypothesis proposed that patients who consistently received SMS reminders would demonstrate higher medication adherence at follow-up ...
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