Search > Major Depressive Disorder
My employer runs this trial

Transcranial Direct Current Stimulation for Depression

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of California, San Diego
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This study aims to evaluate the clinical efficacy and neurophysiological mechanisms of home-based spaced tDCS in TRD through a randomized, double-blind, sham-controlled trial conducted under remote supervision. Specifically, this trial will: (1) compare the efficacy of active versus sham spaced tDCS on depressive symptom severity in individuals with TRD and (2) characterize neurophysiological changes associated with spaced tDCS using TMS-EEG, TMS-EMG and resting state EEG.

Are You a Good Fit for This Trial?

This trial is for adults with major depressive disorder who have not improved after trying other depression treatments. Participants must be able to use the tDCS device at home and take part in remote supervision.

Inclusion Criteria

Able to read, understand, and provide written, dated informed consent prior to screening with proficiency in English sufficient to complete questionnaires and follow instructions during interventions
MADRS score of ≥20 at screening
For persons of childbearing potential: must take pregnancy test prior to treatment initiation with negative results confirmed by study staff
See 9 more

Exclusion Criteria

Significant comorbid obsessive-compulsive or post-traumatic stress disorder
Previously diagnosed Intellectual Disability or Autism Spectrum Disorder
Pregnancy including breastfeeding or trying to become pregnant
See 16 more

What Are the Treatments Tested in This Trial?

Interventions

  • Spaced Transcranial Direct Current Stimulation (tDCS)

Trial Overview

The study compares real versus fake (sham) transcranial direct current stimulation (tDCS), a non-invasive brain stimulation, delivered at home under remote monitoring, to see if it helps people with treatment-resistant depression.

How Is the Trial Designed?

2

Treatment groups

Active Control

Placebo Group

Group I: Active spaced-tDCSActive Control1 Intervention
Group II: Sham spaced-tDCSPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, San Diego

Lead Sponsor

Trials
1,215
Recruited
1,593,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+

Unbiased Results

We believe in providing patients with all the options.

Your Data Stays Your Data

We only share your information with the clinical trials you're trying to access.

Verified Trials Only

All of our trials are run by licensed doctors, researchers, and healthcare companies.