CAMS Therapy for Suicidal Thoughts
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores brain function in young people with suicidal thoughts and behaviors. Researchers aim to understand brain changes in individuals at varying suicide risk levels and assess how a specific therapy, called CAMS (Collaborative Assessment and Management of Suicidality), might help. CAMS involves working closely with a therapist to address the reasons behind suicidal thoughts. The trial seeks participants aged 14-24 who have recently attempted suicide, have experienced suicidal thoughts for a year, or have no history of suicidal thoughts or actions. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could improve mental health treatments for young people.
Do I need to stop my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications. However, if you are taking amphetamines for ADHD, you will not be excluded from the study.
What prior data suggests that CAMS therapy is safe for treating suicidal thoughts?
Previous studies have shown that CAMS therapy quickly and effectively reduces suicidal thoughts for an extended period. Research indicates that CAMS not only lowers these thoughts but also reduces overall distress and related risk factors. Importantly, CAMS is well-tolerated and often leads to better treatment outcomes compared to other methods. Participants in these studies generally did not report any serious side effects, suggesting that CAMS is a safe treatment option for those struggling with suicidal thoughts.12345
Why are researchers excited about this trial?
Researchers are excited about the CAMS Therapy for suicidal thoughts because it offers a personalized approach to managing suicidality, different from typical treatments like medication or generalized therapy. This method involves collaborative assessment and management, where patients actively participate in identifying and addressing their suicidal thoughts and behaviors. This direct involvement can lead to more tailored and effective interventions, potentially improving outcomes and providing a sense of empowerment for patients. By focusing on understanding the individual’s specific issues and developing a personalized treatment plan, CAMS could revolutionize how we approach and treat suicidal ideation.
What evidence suggests that CAMS therapy might be an effective treatment for suicidal thoughts?
Research has shown that the Collaborative Assessment and Management of Suicidality (CAMS) effectively reduces suicidal thoughts and distress. Studies have found that CAMS quickly and consistently lowers thoughts of suicide and overall distress from symptoms. Specifically, CAMS has outperformed other treatments, resulting in significantly lower levels of suicidal thoughts. Patients also experience better treatment outcomes and develop stronger relationships with their therapists. These findings suggest that CAMS offers a promising approach for helping individuals with suicidal thoughts. Participants in this trial will be categorized into high-risk, medium-risk, and minimal-risk groups to evaluate CAMS's effectiveness across varying levels of suicidal risk.12678
Who Is on the Research Team?
Tatiana Falcone, M.D.
Principal Investigator
The Cleveland Clinic
Are You a Good Fit for This Trial?
This trial is for English-speaking youth ages 14-24. It includes those recently hospitalized after a suicide attempt, those with ongoing suicidal thoughts but no attempts, and healthy controls without any history of suicidal thoughts or psychiatric issues. Participants must be able to give consent.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo baseline neuroimaging and psychiatric assessments
Treatment
High-risk participants receive CAMS therapy, typically involving weekly sessions
Post-Treatment Assessment
Repeat neuroimaging and clinical assessments to evaluate treatment-related changes
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Collaborative Assessment and Management of Suicidality (CAMS)
Trial Overview
The study uses brain scans (MEG and MRI) and mental health assessments to compare brain activity in high-risk, medium-risk, and low-risk youth. High-risk participants also receive CAMS therapy—a collaborative talk therapy—to see how it affects their brains before and after treatment.
How Is the Trial Designed?
3
Treatment groups
Active Control
patients discharged within 1 week from the hospital for a SA and with a history of 2 previous SAs
patients with 1 year history of SI with no attempts
age-matched controls with no prior history of SI or behavior, not taking any psychotropic medication and no family history of suicide
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Cleveland Clinic
Lead Sponsor
MQ Mental Health Research
Collaborator
Citations
Collaborative Assessment and Management of Suicidality ...
So far, results are promising and suggest that CAMS is superior to other approaches and leads to a rapid and sustained reduction of suicidal ideation, overall ...
The Collaborative Assessment and Management of ...
Results suggest that CAMS leads to a rapid and sustained reduction of suicidal ideation, overall symptom distress, and related risk factors such as ...
2021-Swift-et-al.-SLTB-1.pdf
Results: In comparison to alternative interventions, CAMS resulted in significantly lower suicidal ideation (d = 0.25) and general distress (d = ...
study protocol for a randomized controlled trial
In this randomized controlled trial (RCT) we are investigating whether CAMS is more effective than Enhanced-Treatment as Usual (E-TAU) in reducing suicidal ...
The effectiveness of the Collaborative Assessment and ...
In comparison to alternative interventions, CAMS resulted in significantly lower suicidal ideation (d = 0.25) and general distress (d = 0.29), ...
6.
cams-care.com
cams-care.com/wp-content/uploads/2024/07/Study-Protocol_CAMS_-BMCPsychiatry_finale-Version.pdfCollaborative Assessment and Management of Suicidality ( ...
The primary outcome in the trial is the change in sui- cidal ideation severity from baseline measure (t1) to post assignment (t2) and the follow-up assignments ...
study protocol for a randomized controlled trial - PMC
In this pragmatic randomized controlled trial (RCT) we will investigate if CAMS is more effective than treatment as usual (TAU) in reducing suicidal thoughts ...
8.
campaigns.dmu.edu
campaigns.dmu.edu/virtual-library/R4tgqj/2AD072/CollaborativeAssessmentAndManagementOfSuicidalityCams.pdfCOLLABORATIVE ASSESSMENT AND MANAGEMENT ...
Research has demonstrated that CAMS can reduce suicidal ideation and behaviors, improve treatment outcomes, and enhance the therapeutic alliance between ...
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