Dental Treatments for Tooth Decay
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores two dental treatments to determine which is more effective for tooth decay. One group receives silver diamine fluoride (SDF) applied twice a year, while the other group undergoes atraumatic restorative treatment (ART) with glass ionomer cement plus fluoride varnish. The trial targets older adults who previously participated in the study and have untreated cavities. Participants must remain involved for at least another year. The study aims to determine which treatment maintains healthier teeth over the long term. As an unphased trial, it offers participants the chance to contribute to valuable research that could enhance dental care for others.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It seems likely that you can continue your medications, but it's best to confirm with the study team.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Previous studies have shown that silver diamine fluoride (SDF) effectively stops tooth decay. However, it can cause permanent black staining on treated areas of teeth, the most common side effect, which does not affect the treatment's overall safety.
Research indicates that atraumatic restorative treatment (ART) with glass ionomer cement (GIC) gently treats tooth decay. Simple hand tools clean the cavity, and a special cement is applied to protect it. The fluoride varnish in this treatment helps prevent further decay and is generally well-tolerated.
Both treatments have been widely used and are considered safe for most people. This trial does not involve a new treatment, so existing data and experience provide the safety information.12345Why are researchers excited about this trial's treatments?
Researchers are excited about these treatments for tooth decay because they offer potential new ways to manage cavities with less invasive techniques. Silver Diamine Fluoride (SDF) is unique because it not only arrests decay but also reinforces the tooth structure and prevents further damage, all with a simple application. Unlike traditional fillings, which often require drilling, Atraumatic Restorative Treatment (ART) with Glass Ionomer Cement (GIC) minimizes discomfort by restoring the tooth with a less invasive approach and adding the protective benefits of fluoride varnish. These treatments aim to simplify the dental care process, making it more accessible and less intimidating for patients.
What evidence suggests that this trial's treatments could be effective for tooth decay?
Research has shown that Silver Diamine Fluoride (SDF), one of the treatments in this trial, effectively stops tooth decay. Studies have found that applying SDF twice a year can halt cavities and is particularly beneficial in community settings. However, it may cause permanent black stains on treated areas. Another treatment option in this trial, Atraumatic Restorative Treatment (ART) using Glass Ionomer Cement (GIC) and Fluoride Varnish (FV), effectively manages tooth decay, especially for cavities on a single surface. GIC has been shown to reduce the risk of new cavities by 76% on healthy teeth. Both treatments have strong evidence supporting their effectiveness in treating tooth decay.678910
Who Is on the Research Team?
Suchitra S Nelson, PhD
Principal Investigator
Case Western Reserve University
Are You a Good Fit for This Trial?
This trial is for community-dwelling older adults aged 62 or above with untreated tooth decay, who participated in the original study and consent to a long-term follow-up. They must be willing to stay in the study for another year and have completed prior treatment phases. Those with silver sensitivity, serious diseases, or certain oral health issues are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive biannual silver diamine fluoride (SDF) or atraumatic restorative treatment (ART) with glass ionomer cement (GIC) and biannual fluoride varnish (FV) application for new decay
Follow-up
Participants are monitored for safety and effectiveness after treatment
Long-term follow-up
Participants contribute data at 3 to 6 years post-randomization to assess clinical equipoise of the two treatments
What Are the Treatments Tested in This Trial?
Interventions
- Atraumatic Restorative Treatment with Glass Ionomer Cement + Fluoride Varnish
- Silver Diamine Fluoride
Find a Clinic Near You
Who Is Running the Clinical Trial?
Case Western Reserve University
Lead Sponsor
Patient-Centered Outcomes Research Institute
Collaborator