Brain Stimulation for Dementia

(BWIBS-WM Trial)

This trial aims to improve working memory in people with dementia using a method called EEG-triggered transcranial magnetic stimulation (TMS). TMS safely and non-invasively sends brief electrical currents to the brain, helping brain waves realign. The goal is to ease daily tasks like conversations and remembering lists for dementia patients, potentially reducing the burden on their families. Individuals diagnosed with Alzheimer's Disease or related dementias who can understand English instructions might be suitable candidates for this trial. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance daily life for dementia patients.

Research has shown that transcranial magnetic stimulation (TMS) is generally well-tolerated by individuals with mild memory problems. Studies have found that TMS can be safely combined with EEG, a test that measures brain waves, to study brain activity and potentially enhance thinking skills.

For instance, one study found that TMS, when used with EEG, had manageable side effects in people with mild memory issues. Another review found that repetitive TMS (rTMS), a similar treatment, provided moderate improvements in thinking skills and was particularly effective at higher frequencies.

Researchers are excited about EEG-triggered Transcranial Magnetic Stimulation (TMS) because it offers a new way to potentially enhance working memory in dementia patients. Unlike standard treatments like medications that aim to manage symptoms, EEG-triggered TMS uses real-time brain wave monitoring to precisely deliver magnetic stimulation to specific brain areas involved in memory. This approach could lead to more targeted and effective interventions by synchronizing the treatment with the brain's natural rhythms. This innovative method holds promise for improving cognitive function in ways traditional treatments cannot.

This trial will investigate EEG-triggered transcranial magnetic stimulation (TMS) for dementia. Studies have shown that combining TMS with EEG, a test measuring brain activity, may enhance thinking skills in people with dementia. Research suggests that TMS can improve the coordination of brain waves, which is crucial for memory. In individuals with Alzheimer's disease, TMS has been linked to enhanced overall cognitive abilities. Specifically, TMS can improve memory by aligning brain waves, aiding tasks like remembering lists or following directions. Overall, strong evidence indicates that EEG-guided TMS can positively impact thinking skills in dementia.¹²³⁵⁶